Radiation treatment methods in uveal melanoma

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Tsotridou Eleni; Loukovitis Eleftherios; Tsiropoulos Georgios N.; Zapsalis Konstantinos; Pentara Iro; Tzima Konstantina; Eminidou Valeria; Anogeianakis George

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Journal Paper

Paper Information

Journal: MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY Year:2021 | Volume:10 | Issue:1 Page(s): 32-42

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Information Journal Paper

Title

Radiation treatment methods in uveal melanoma

Author(s)

Keywords

melanoma of the uvea

choroidal melanoma

radiation therapy

brachytherapy

radioisotope brachytherapy

proton beam therapy

classification

Abstract

Background: The most frequent primary ocular malignancy in the western world is the uveal melanoma. While it mainly affects Caucasians, it is extremely uncommon among non-Caucasians. Continuous improvement in therapies for local treatment has allowed sparing of the eye, although this approach apparently does not improve survival. The present review aimed to explain different radiotherapy (RT) methods and compare the pros and cons of each method, along with the main complications that may be encountered in the treatment of uveal melanoma. Methods: Relevant papers published between September 2009 and January 2021 were retrieved, reviewed, and screened. Four databases, including PubMed, MEDLINE, Google Scholar, and GeneCards, were searched for this purpose. Results: Forty-one relevant articles were identified. Based on the selected papers, we highlighted the advantages and disadvantages of the different RT methods that have allowed sparing of the eye, even though they have not, as yet, improved survival. We listed a detailed comparison between therapies that allow an educated choice among the different available RT methods. Conclusion: The choice of uveal melanoma management is determined by the location of the tumor and volume of the extraocular extent. At present, there is no gold standard for the management of all ocular melanomas, and each case should be approached individually. Therefore, classification is a valuable prognostic tool. Many cases in cT3-4 classification categories are treated by primary enucleation and conservative treatment follow-up, while in cT2 and most cT1 classifications (i. e., 3. 1– 6. 0-mm tumor thickness), several forms of RT are used.

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APA: Copy

Tsotridou, Eleni, Loukovitis, Eleftherios, Tsiropoulos, Georgios N., Zapsalis, Konstantinos, Pentara, Iro, Tzima, Konstantina, Eminidou, Valeria, & Anogeianakis, George. (2021). Radiation treatment methods in uveal melanoma. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, 10(1), 32-42. SID. https://sid.ir/paper/687960/en

Vancouver: Copy

Tsotridou Eleni, Loukovitis Eleftherios, Tsiropoulos Georgios N., Zapsalis Konstantinos, Pentara Iro, Tzima Konstantina, Eminidou Valeria, Anogeianakis George. Radiation treatment methods in uveal melanoma. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY[Internet]. 2021;10(1):32-42. Available from: https://sid.ir/paper/687960/en

IEEE: Copy

Eleni Tsotridou, Eleftherios Loukovitis, Georgios N. Tsiropoulos, Konstantinos Zapsalis, Iro Pentara, Konstantina Tzima, Valeria Eminidou, and George Anogeianakis, “Radiation treatment methods in uveal melanoma,” MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, vol. 10, no. 1, pp. 32–42, 2021, [Online]. Available: https://sid.ir/paper/687960/en

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