The Effect of Probiotic Yogurt on the Frequency of Clostridium Difficile in Old Hospitalized Patients

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SOFIAN MASOOMEH; Eghbal Elahe; GHAZNAVI RAD EHSANOLLAH; RAMEZANI AMITIS; MOHAGHEGH PEGAH

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Journal: Journal of Arak University Medical Sciences Year:2019 | Volume:22 | Issue:4 Page(s): 52-65

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Title

The Effect of Probiotic Yogurt on the Frequency of Clostridium Difficile in Old Hospitalized Patients

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Clostridium difficileQ1

Probiotic yogurtQ2

Abstract

Background and Aim Clostridium difficile is the main cause of Antibiotic-Associated Diarrhea (AAD) in the hospital setting. Today, the use of probiotics for the prevention and treatment of AAD and colitis is increasing. In this study, we investigated the effect of Probiotic yogurt on the frequency of Clostridium difficile. Methods and Materials In this randomized clinical trial study, 132 elderly patients admitted to the infectious ward of Vali-e-Asr Hospital in Arak, who were under antibiotic treatment, were randomly divided into two groups, case (yogurt probiotic, 200 mg/d for 8 days) and control group (common yogurt). All patients were trained about the signs of colitis. We evaluated the colitis signs and the presence of Clostridium difficile by Polymerase Chain Reaction (PCR) and compared them between the groups. The obtained data were analyzed with appropriate statistical tests in SPSS V. 16. Ethical Considerations The Research Ethics Committee of Arak University of Medical Sciences approved this study (Code: 10-165-93). Also, it was registered at the Iranian Registry of Clinical Trials (Code: IRCT2016092229915N1). Results Clostridium difficile was detected in 4 (6. 1%) patients of the case, and 1 (1. 5%) patient of the control group, at the beginning of the study. There was no significant difference between the frequency of Clostridium difficile and colitis syndrome between two groups at the end of the study (P>0. 05). Conclusion Probiotic yogurt has no significant effect in reducing the frequency of Clostridium difficile and colitis syndrome in our study.

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APA: Copy

SOFIAN, MASOOMEH, Eghbal, Elahe, GHAZNAVI RAD, EHSANOLLAH, RAMEZANI, AMITIS, & MOHAGHEGH, PEGAH. (2019). The Effect of Probiotic Yogurt on the Frequency of Clostridium Difficile in Old Hospitalized Patients. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 22(4 ), 52-65. SID. https://sid.ir/paper/68846/en

Vancouver: Copy

SOFIAN MASOOMEH, Eghbal Elahe, GHAZNAVI RAD EHSANOLLAH, RAMEZANI AMITIS, MOHAGHEGH PEGAH. The Effect of Probiotic Yogurt on the Frequency of Clostridium Difficile in Old Hospitalized Patients. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;22(4 ):52-65. Available from: https://sid.ir/paper/68846/en

IEEE: Copy

MASOOMEH SOFIAN, Elahe Eghbal, EHSANOLLAH GHAZNAVI RAD, AMITIS RAMEZANI, and PEGAH MOHAGHEGH, “The Effect of Probiotic Yogurt on the Frequency of Clostridium Difficile in Old Hospitalized Patients,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 22, no. 4 , pp. 52–65, 2019, [Online]. Available: https://sid.ir/paper/68846/en

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