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Information Journal Paper

Title

EFFECTS OF ORAL VITAMIN E ON TREATMENT OF ATOPIC DERMATITIS: A RANDOMIZED CONTROLLED TRIAL

Pages

  0-0

Keywords

ATOPIC DERMATITIS (AD) 

Abstract

 Background: The pathogenesis of atopic dermatitis (AD) remains to be determined; recently a possible change in the immune systemwith production of immunoglobulins is proposed. As VITAMIN E is a potent antioxidant, with the ability to decrease the serum levels ofimmunoglobulin E (IgE) in atopic patients, we aimed to evaluate the effect of oral VITAMIN E on TREATMENT of AD. Materials and Methods: Thisrandomized, double-blind, placebo-controlled trial comprised seventy participants with mild-to-moderate AD, based on the Hanifin andRajka diagnostic criteria. The patients were randomly selected from teaching skin clinics in Isfahan, Iran. They were randomly assigned totwo groups of equal number, receiving VITAMIN E (400 IU/day) and placebo for four 4 months. Each month, the extent, severity, and subjectivesymptoms including itch and sleeplessness were measured by SCORAD INDEX. Three months after the end of intervention, the recurrencerate was assessed.Results: The improvement in all symptoms, except sleeplessness, was significantly higher in the group receiving vitaminE than in controls (–1.5 vs.0.218 in itching, –10.85 vs. –3.54 in extent of lesion, and –11.12 vs. –3.89 in SCORAD INDEX, respectively, P<0.05). Three months after the end of intervention, the recurrence rate of AD was evaluated. Recurrence rate between all 42 individuals, whoremained in the study, was 18.6%. Recurrence ratio of the group receiving VITAMIN E compared to the placebo group was 1.17, without significantdifferences between the two groups (P>0.05).Conclusion: This study suggests that VITAMIN E can improve the symptoms and the qualityof life in patients with AD. As VITAMIN E has no side effects with a dosage of 400 IU/day, it can be recommended for the TREATMENT of AD.

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    APA: Copy

    JAFFARY, FARIBA, FAGHIHI, GITA, MOKHTARIAN, ARGHAVAN, & HOSSEINI, SEYED MOHSEN. (2015). EFFECTS OF ORAL VITAMIN E ON TREATMENT OF ATOPIC DERMATITIS: A RANDOMIZED CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(11), 0-0. SID. https://sid.ir/paper/688538/en

    Vancouver: Copy

    JAFFARY FARIBA, FAGHIHI GITA, MOKHTARIAN ARGHAVAN, HOSSEINI SEYED MOHSEN. EFFECTS OF ORAL VITAMIN E ON TREATMENT OF ATOPIC DERMATITIS: A RANDOMIZED CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(11):0-0. Available from: https://sid.ir/paper/688538/en

    IEEE: Copy

    FARIBA JAFFARY, GITA FAGHIHI, ARGHAVAN MOKHTARIAN, and SEYED MOHSEN HOSSEINI, “EFFECTS OF ORAL VITAMIN E ON TREATMENT OF ATOPIC DERMATITIS: A RANDOMIZED CONTROLLED TRIAL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 11, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/688538/en

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