SIGNALING MOLECULES GOVERNING PLURIPOTENCY AND EARLY LINEAGE COMMITMENTS IN HUMAN PLURIPOTENT STEM CELLS (REVIEW ARTICLE)

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FATHI ALI; EISA BEYGI SHAHRAM; BAHARVAND HOSSEIN

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2017 | Volume:19 | Issue:2 Page(s): 194-203

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Information Journal Paper

Title

SIGNALING MOLECULES GOVERNING PLURIPOTENCY AND EARLY LINEAGE COMMITMENTS IN HUMAN PLURIPOTENT STEM CELLS (REVIEW ARTICLE)

Author(s)

FATHI ALI | EISA BEYGI SHAHRAM | BAHARVAND HOSSEIN | Issue Writer Certificate

Keywords

DIFFERENTIATION

STEM CELL

NODAL

Abstract

Signaling in pluripotent STEM CELLs is a complex and dynamic process involving multiple mediators, finely tuned to balancing pluripotency and DIFFERENTIATION states. Characterizing and modifying the necessary signaling pathways to attain desired cell types is required for stem-cell applications in various fields of regenerative medicine. These signals may help enhance the DIFFERENTIATION potential of pluripotent cells towards each of the embryonic lineages and enable us to achieve pure in vitro cultures of various cell types. This review provides a timely synthesis of recent advances into how maintenance of pluripotency in hPSCs is regulated by extrinsic cues, such as the fibroblast growth factor (FGF) and ACTIVIN signaling pathways, their interplay with other signaling pathways, namely, wingless-type MMTV integration site family (WNT) and mammalian target of rapamycin (mTOR), and the pathways governing the determination of multiple lineages.

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References

LRP6 DIMERIZATION THROUGH ITS LDLR DOMAIN IS REQUIRED FOR ROBUST CANONICAL WNT PATHWAY ACTIVATION

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APA: Copy

FATHI, ALI, EISA BEYGI, SHAHRAM, & BAHARVAND, HOSSEIN. (2017). SIGNALING MOLECULES GOVERNING PLURIPOTENCY AND EARLY LINEAGE COMMITMENTS IN HUMAN PLURIPOTENT STEM CELLS (REVIEW ARTICLE). CELL JOURNAL (YAKHTEH), 19(2), 194-203. SID. https://sid.ir/paper/688566/en

Vancouver: Copy

FATHI ALI, EISA BEYGI SHAHRAM, BAHARVAND HOSSEIN. SIGNALING MOLECULES GOVERNING PLURIPOTENCY AND EARLY LINEAGE COMMITMENTS IN HUMAN PLURIPOTENT STEM CELLS (REVIEW ARTICLE). CELL JOURNAL (YAKHTEH)[Internet]. 2017;19(2):194-203. Available from: https://sid.ir/paper/688566/en

IEEE: Copy

ALI FATHI, SHAHRAM EISA BEYGI, and HOSSEIN BAHARVAND, “SIGNALING MOLECULES GOVERNING PLURIPOTENCY AND EARLY LINEAGE COMMITMENTS IN HUMAN PLURIPOTENT STEM CELLS (REVIEW ARTICLE),” CELL JOURNAL (YAKHTEH), vol. 19, no. 2, pp. 194–203, 2017, [Online]. Available: https://sid.ir/paper/688566/en

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