The Effect of Exercise with Different Intensity on Glucose Transporter 4 (GLUT4) Gene Expression in Skeletal Muscle of Obese Male Rats

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Najafi Mahnaz; ASAD MOHAMMAD REZA; RAHIMI MOSTAFA; SOURI RAHMAN; AHVAR ALI

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:21 | Issue:4 (133) Page(s): 98-108

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Title

The Effect of Exercise with Different Intensity on Glucose Transporter 4 (GLUT4) Gene Expression in Skeletal Muscle of Obese Male Rats

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Keywords

Glucose transporter 4Q1

Moderate-intensity continuous trainingQ1

High intensity interval trainingQ1

Skeletal muscleQ2

Abstract

Background and Aim: The aim of study was to investigate the effect of 8 weeks of Moderate-intensity continuous training (MICT) and High intensity interval training (HIIT) on the GLUT4 gene expression in Skeletal muscle of obese male rats. Materials and Methods: Twenty-eight male Wistar rats with 150  25 grams body weight were divided into base control (n = 6), obese control (n = 6), MICT (n = 8), and (n = 8) HIIT groups as study sample. At the beginning of the study, base control group rats were sacrificed. In other groups, rats underwent high fat regime diet for 8 weeks. After one week of familiarization, rats in training groups run on treadmill for 8 weeks and 5 days per week. Forty-eight hours after the last session, the rats were scarified and gastrocnemius muscle tissue sample were removed. GLUT4 gene expression was measured by Real-Time PCR methods. Findings: Results indicated that high fat diet for 8 weeks significantly increased rats body weight (p= 0. 001), whereas both of MICT and HIIT training significantly decreased body weight (p= 0. 001). Moreover, the MICT and HIIT had significant increase in GLUT4 gene expression in gastrocnemius muscle of obese rats (p = 0. 001). Although, there were no differences between two experimental groups (p = 0. 99). Conclusion: According to the results, the MICT and HIIT increase gene expression of GLUT4 in mixed muscle fibers in obese rats.

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APA: Copy

Najafi, Mahnaz, ASAD, MOHAMMAD REZA, RAHIMI, MOSTAFA, SOURI, RAHMAN, & AHVAR, ALI. (2018). The Effect of Exercise with Different Intensity on Glucose Transporter 4 (GLUT4) Gene Expression in Skeletal Muscle of Obese Male Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(4 (133) ), 98-108. SID. https://sid.ir/paper/68859/en

Vancouver: Copy

Najafi Mahnaz, ASAD MOHAMMAD REZA, RAHIMI MOSTAFA, SOURI RAHMAN, AHVAR ALI. The Effect of Exercise with Different Intensity on Glucose Transporter 4 (GLUT4) Gene Expression in Skeletal Muscle of Obese Male Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(4 (133) ):98-108. Available from: https://sid.ir/paper/68859/en

IEEE: Copy

Mahnaz Najafi, MOHAMMAD REZA ASAD, MOSTAFA RAHIMI, RAHMAN SOURI, and ALI AHVAR, “The Effect of Exercise with Different Intensity on Glucose Transporter 4 (GLUT4) Gene Expression in Skeletal Muscle of Obese Male Rats,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 4 (133) , pp. 98–108, 2018, [Online]. Available: https://sid.ir/paper/68859/en

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