The Study of Effect of Nilutamide (An Androgen Receptor Antagonist) on Spatial Learning And Memory in Adolescent Male Rats

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Salimi Zahra; KHAJEHPOUR LOTFOLAH; Moradpour Farshad; MOAZEDI AHMAD ALI; POURMOTABBED ALI

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2019 | Volume:22 | Issue:3 (139) Page(s): 81-94

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Title

The Study of Effect of Nilutamide (An Androgen Receptor Antagonist) on Spatial Learning And Memory in Adolescent Male Rats

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Keywords

Learning and memoryQ2

Morris water mazeQ1

NilutamideQ1

Abstract

Background and Aim: Nilutamide is a pure non-steroidal antiandrogen that is used in the treatment of advanced-stage (metastatic) prostate cancer and acts as a potent and selective antagonist of the androgen receptors. Previous studies showed that there must be relationship between androgen receptors and cognitive aspects of the brain. Therefore, it seems that Nilutamide affects spatial Learning and memory through effect on androgen receptors. The aim of this study is to evaluate the effect of Nilutamide on spatial localization in the Morris water maze and synaptic plasticity at the hippocampus CA1 area of male adolescent rats. Materials and Methods: In this experimental study, male Wistar rats were randomly divided into 4 groups (n=9). Experimantal groups received vehicle (DMSO 10%) as control groups and different doses of Nilutamide (5, 10 and 15μ g/2. 5μ l). Drug and vehicle were injected for 4 days before training. Ethical Considerations: This study with research ethics code EE/ 97, 24, 3061300/ scu. ac. ir has been approved by research ethics committee at Shahid Chamran University of Ahvaz. Findings: Analysis showed that escape latency and traveled distance for finding hidden platform in the group which received Nilutamide (15μ g) were significantly lower than of control group at first (p < 0. 05) and second (p < 0. 01) training days. The results of field potential recording showed that Nilutamide had not any significant effect on fEPSP and PS. Conclusion: The results of peresent study releaved that i. c. v microinjection of Nilutamide improved spatial learninig in first and second days, wherease increase of treatment (4 days) not affected spatial learning.

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References

Differential ability of the dorsal and ventral rat hippocampus to exhibit group I metabotropic glutamate receptor– dependent synaptic and intrinsic plasticity

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APA: Copy

Salimi, Zahra, KHAJEHPOUR, LOTFOLAH, Moradpour, Farshad, MOAZEDI, AHMAD ALI, & POURMOTABBED, ALI. (2019). The Study of Effect of Nilutamide (An Androgen Receptor Antagonist) on Spatial Learning And Memory in Adolescent Male Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 22(3 (139) ), 81-94. SID. https://sid.ir/paper/68870/en

Vancouver: Copy

Salimi Zahra, KHAJEHPOUR LOTFOLAH, Moradpour Farshad, MOAZEDI AHMAD ALI, POURMOTABBED ALI. The Study of Effect of Nilutamide (An Androgen Receptor Antagonist) on Spatial Learning And Memory in Adolescent Male Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;22(3 (139) ):81-94. Available from: https://sid.ir/paper/68870/en

IEEE: Copy

Zahra Salimi, LOTFOLAH KHAJEHPOUR, Farshad Moradpour, AHMAD ALI MOAZEDI, and ALI POURMOTABBED, “The Study of Effect of Nilutamide (An Androgen Receptor Antagonist) on Spatial Learning And Memory in Adolescent Male Rats,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 22, no. 3 (139) , pp. 81–94, 2019, [Online]. Available: https://sid.ir/paper/68870/en

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