مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 GENE POLYMORPHISM (RS568408 G/A) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION

Pages

  21-25

Abstract

 Introduction: Hepatitis B is a potentially life-threatening infection that causes acute infection and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (HCC). Interleukin-12 (IL12) is responsible for activation of Th1 immune responses, leading to possible clearance of HBV infection from the host’s body. The host’s immune-genetic background plays an important role in the pathogenesis of infectious diseases. The aim of the present study was to investigate the association of INTERLEUKIN 12A single nucleotide polymorphism (rs568408 G/A) with chronic HBV infection.Methods: In this case-control study, 120 chronic HBV patients and 120 healthy controls were studied from 2013 to 2015. Genotype analysis was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results: The genotype distribution of IL12 rs568408 G/A was not significantly different between the chronic HBV patients and healthy controls. The frequency rates of the IL12 gene polymorphism at position rs568408 included GG (64.2%), AG (33.3%), and AA (2.5%) in the HBV patients and GG (68.3%), AG (29.2%), and AA (2.5%) in healthy controls (p=0.728).Conclusion: The results suggested no significant association between IL12A rs568408 G/A genotypes and chronic hepatitis B virus infection.

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    APA: Copy

    HEIDARIAN, SEDDIGHEH, SABAHI, FARZANEH, MOHEBBI, SEYED REZA, & ZALI, MOHAMMAD REZA. (2016). LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 GENE POLYMORPHISM (RS568408 G/A) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 20(1), 21-25. SID. https://sid.ir/paper/688753/en

    Vancouver: Copy

    HEIDARIAN SEDDIGHEH, SABAHI FARZANEH, MOHEBBI SEYED REZA, ZALI MOHAMMAD REZA. LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 GENE POLYMORPHISM (RS568408 G/A) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2016;20(1):21-25. Available from: https://sid.ir/paper/688753/en

    IEEE: Copy

    SEDDIGHEH HEIDARIAN, FARZANEH SABAHI, SEYED REZA MOHEBBI, and MOHAMMAD REZA ZALI, “LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 GENE POLYMORPHISM (RS568408 G/A) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 20, no. 1, pp. 21–25, 2016, [Online]. Available: https://sid.ir/paper/688753/en

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