MORPHOMETRY OF RAT JEJUNAL ENTEROCYTES NUMBER AND HEIGHT AFTER L-ARGININE AND L-NAME ADMINISTRATION

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NOORI MUGAHI SEYED MOHAMMAD HOSSEIN

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Journal: Zahedan Journal of Research in Medical Sciences Year:2015 | Volume:17 | Issue:2 Page(s): 0-0

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Title

MORPHOMETRY OF RAT JEJUNAL ENTEROCYTES NUMBER AND HEIGHT AFTER L-ARGININE AND L-NAME ADMINISTRATION

Author(s)

NOORI MUGAHI SEYED MOHAMMAD HOSSEIN | Issue Writer Certificate

Keywords

NITRIC OXIDE

L-ARGININE

L-NAME

EPITHELIAL CELL

JEJUNUM

Abstract

Background: Nowadays NITRIC OXIDE (NO) is an important signaling molecule which actsas a regulator of many physiological processes in many tissues including EPITHELIAL CELL ofgastrointestinal tract. In this study, we investigated the effects of L-Argentine as a NOprecursor and L-NAME as a NO inhibitor on EPITHELIAL CELL number and height of jejunaepithelium in rats.Materials and Methods: In this experimental study, 40 adult female rats with 8 weeks ageand 200-250 g weight were divided into 5 groups, containing 8 rats in each group. Exceptthe control group, the other groups received normal saline (2 mL/kg), L-Argentine (200mg/kg), L-NAME (20 mg/kg) and a mixture of 2 substances for L-argentine and L-NAMEgroup intraperitonealy for 3 days. Two weeks later, JEJUNUM was expelled out and afterfixation and tissue processing, the sections were stained with Hematoxylin & Eosinmethod and the changes were assessed. Cell number and height was evaluated using ImageTools III Microsoft software. Statistical analysis was made by One-Way ANOVAfollowed by Tukey post hoc test to evaluate the statistical significance between differentgroups. A value of p<0.05 was considered statistically significant.Results: There was a significant increase in the cell number and height of jejunaepithelium in L-Argentine group (p<0.05). Whereas no significant difference wasobserved between L-NAME, L-ARGININE+L-NAME, normal saline and control groups.Conclusion: The results demonstrated that L-Argentine can result in proliferation ofjejuna EPITHELIAL CELLs whereas L-NAME has no effect on these cells.

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APA: Copy

NOORI MUGAHI, SEYED MOHAMMAD HOSSEIN. (2015). MORPHOMETRY OF RAT JEJUNAL ENTEROCYTES NUMBER AND HEIGHT AFTER L-ARGININE AND L-NAME ADMINISTRATION. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(2), 0-0. SID. https://sid.ir/paper/688809/en

Vancouver: Copy

NOORI MUGAHI SEYED MOHAMMAD HOSSEIN. MORPHOMETRY OF RAT JEJUNAL ENTEROCYTES NUMBER AND HEIGHT AFTER L-ARGININE AND L-NAME ADMINISTRATION. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(2):0-0. Available from: https://sid.ir/paper/688809/en

IEEE: Copy

SEYED MOHAMMAD HOSSEIN NOORI MUGAHI, “MORPHOMETRY OF RAT JEJUNAL ENTEROCYTES NUMBER AND HEIGHT AFTER L-ARGININE AND L-NAME ADMINISTRATION,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/688809/en

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