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Information Journal Paper

Title

INVESTIGATING THE ANTICONVULSANT EFFECTS OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON PERFORANT PATH KINDLING MODEL IN RATS

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  0-0

Abstract

 Background: Almost 20% of epileptics are drug resistant. Studies have shown that lowfrequency repetitive transCRANIAL MAGNETIC STIMULATION (rTMS) is with therapeutic effectson EPILEPSY-affected laboratory models. Anticonvulsant effects of rTMS depend on severalparameters among which radiation frequency is the most important one. In this study, thetherapeutic impacts of 1 and 2 Hz rTMS on convulsing parameters in epileptic model ofelectrical kindling stimulation of the perforant path were investigated.Materials and Methods: In this experimental study 21 rats were randomly divided intothree groups, namely ‘1 Hz treatment group’ and ‘2 Hz treatment group’ and ‘kindlinggroup’. The kindling group only received kindling stimulations for seven days. One Hzand 2 Hz frequency treatment groups received maximally 5 min rTMS after termination ofkindling stimulation per day for a week. Stimulation and stability electrodes had beenplaced, in turn, on perforant path and DENTATE GYRUS. For quantifying the duration of thesubsequent discharge waves, two-way ANOVA test and Bonferroni post-test wereemployed. In addition, for quantifying the convulsive behaviors, Kruskal-Wallis and theMann-Whitney U tests were used.Results: The results showed that 1 Hz and 2 Hz frequency rTMS have considerableinhibitory impact on the development of convulsive phases. Anticonvulsive effect wasobserved from the first day after rTMS was undertaken. In addition, the animals did notshow fourth and fifth convulsive stages, and a significant reduction was evident in theirrecorded peak discharge waves compared with kindle group.Conclusion: Low frequency rTMS possesses significant anticonvulsive effects whichdepend upon sTMS stimulation frequency.

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    APA: Copy

    YADOLLAHPOUR, ALI. (2015). INVESTIGATING THE ANTICONVULSANT EFFECTS OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON PERFORANT PATH KINDLING MODEL IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(2), 0-0. SID. https://sid.ir/paper/688810/en

    Vancouver: Copy

    YADOLLAHPOUR ALI. INVESTIGATING THE ANTICONVULSANT EFFECTS OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON PERFORANT PATH KINDLING MODEL IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(2):0-0. Available from: https://sid.ir/paper/688810/en

    IEEE: Copy

    ALI YADOLLAHPOUR, “INVESTIGATING THE ANTICONVULSANT EFFECTS OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON PERFORANT PATH KINDLING MODEL IN RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/688810/en

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