CANCER/TESTIS GENES IN RELATION TO SPERM BIOLOGY AND FUNCTION

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BABATUNDE KEHINDE ADEBAYO; NAJAFI ALI; SALEHIPOUR POUYA; MODARRESSI MOHAMMAD HOSSEIN; BEIGOM MOBASHERI MARYAM

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:9 Page(s): 967-974

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Title

CANCER/TESTIS GENES IN RELATION TO SPERM BIOLOGY AND FUNCTION

Author(s)

Keywords

CANCER TESTIS GENES

CARCINOGENESIS

SPERMATOGENESIS

SPERM BIOLOGY

SPERM GENES FUNCTIONS

TESTIS GENES

Abstract

Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to the development of different clinical trials of CTA-based vaccine therapy because of their resilient in vivo immunogenicity and tumor-restricted expression pattern. Bladder cancer, non-small cell lung carcinoma, and melanoma are grouped as high CT gene expressors. Prostate and breast cancer as moderate, and colon and renal cancers are considered as low CT gene expressors. Large percentages of these identified CT genes are expressed during SPERMATOGENESIS but their function is still vaguely unknown. Researchers have taken a keen interest in CT genes as pertaining to their role in tumor growth and SPERMATOGENESIS. Testis has many similarities with cancerous tissues like cell division, immigration, and immortalization. The aim is to give a concise in-depth review on the role of some specific CT genes in SPERMATOGENESIS.

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APA: Copy

BABATUNDE, KEHINDE ADEBAYO, NAJAFI, ALI, SALEHIPOUR, POUYA, MODARRESSI, MOHAMMAD HOSSEIN, & BEIGOM MOBASHERI, MARYAM. (2017). CANCER/TESTIS GENES IN RELATION TO SPERM BIOLOGY AND FUNCTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(9), 967-974. SID. https://sid.ir/paper/688861/en

Vancouver: Copy

BABATUNDE KEHINDE ADEBAYO, NAJAFI ALI, SALEHIPOUR POUYA, MODARRESSI MOHAMMAD HOSSEIN, BEIGOM MOBASHERI MARYAM. CANCER/TESTIS GENES IN RELATION TO SPERM BIOLOGY AND FUNCTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(9):967-974. Available from: https://sid.ir/paper/688861/en

IEEE: Copy

KEHINDE ADEBAYO BABATUNDE, ALI NAJAFI, POUYA SALEHIPOUR, MOHAMMAD HOSSEIN MODARRESSI, and MARYAM BEIGOM MOBASHERI, “CANCER/TESTIS GENES IN RELATION TO SPERM BIOLOGY AND FUNCTION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 9, pp. 967–974, 2017, [Online]. Available: https://sid.ir/paper/688861/en

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