THE EFFECT OF SPINALLY ADMINISTERED WIN 55, 212‐2, A CANNABINOID AGONIST, ON THERMAL PAIN SENSITIVITY IN DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAHANABADI SAMANEH; HADIAN MOHAMMAD REZA; SHAMSAEE JAVAD; TAVANGAR SEYED MOHAMMAD; ABDOLLAHI ALIREZA; DEHPOUR AHMAD REZA; EJTEMAEI MEHR SHAHRAM

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:4 Page(s): 394-401

Download Full-Text

View:

281

Download:

172

Cites:

Information Journal Paper

Title

THE EFFECT OF SPINALLY ADMINISTERED WIN 55, 212‐2, A CANNABINOID AGONIST, ON THERMAL PAIN SENSITIVITY IN DIABETIC RATS

Author(s)

Keywords

DIABETES

INTRATHECAL

NEUROPATHY

PAIN

WIN 55

212‐2

Abstract

Objective (s): Diabetic NEUROPATHY (DN) is a common complication of DIABETES that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high‐affinity cannabinoid receptors agonist, WIN 55, 212‐2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats.Materials and Methods: DIABETES was induced in rats using a single dose of streptozotocin (45 mg/kg IP).Results: INTRATHECAL (IT) administration of WIN55, 212‐2 (1, 10, 100 μ/10 μ, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (100 μ/10 μ, IT) and sciatic nerve histology.Conclusion: These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that INTRATHECALly administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic PAIN.

Cites

No record.

References

No record.

Cite

APA: Copy

JAHANABADI, SAMANEH, HADIAN, MOHAMMAD REZA, SHAMSAEE, JAVAD, TAVANGAR, SEYED MOHAMMAD, ABDOLLAHI, ALIREZA, DEHPOUR, AHMAD REZA, & EJTEMAEI MEHR, SHAHRAM. (2016). THE EFFECT OF SPINALLY ADMINISTERED WIN 55, 212?2, A CANNABINOID AGONIST, ON THERMAL PAIN SENSITIVITY IN DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(4), 394-401. SID. https://sid.ir/paper/689470/en

Vancouver: Copy

JAHANABADI SAMANEH, HADIAN MOHAMMAD REZA, SHAMSAEE JAVAD, TAVANGAR SEYED MOHAMMAD, ABDOLLAHI ALIREZA, DEHPOUR AHMAD REZA, EJTEMAEI MEHR SHAHRAM. THE EFFECT OF SPINALLY ADMINISTERED WIN 55, 212?2, A CANNABINOID AGONIST, ON THERMAL PAIN SENSITIVITY IN DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(4):394-401. Available from: https://sid.ir/paper/689470/en

IEEE: Copy

SAMANEH JAHANABADI, MOHAMMAD REZA HADIAN, JAVAD SHAMSAEE, SEYED MOHAMMAD TAVANGAR, ALIREZA ABDOLLAHI, AHMAD REZA DEHPOUR, and SHAHRAM EJTEMAEI MEHR, “THE EFFECT OF SPINALLY ADMINISTERED WIN 55, 212?2, A CANNABINOID AGONIST, ON THERMAL PAIN SENSITIVITY IN DIABETIC RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 4, pp. 394–401, 2016, [Online]. Available: https://sid.ir/paper/689470/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops