Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients

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LAO THUAN DUC; Nguyen Minh Trong; Nguyen Dung Huu; HUYEN LE THUY AI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2021 | Volume:50 | Issue:8 Page(s): 1642-1647

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Information Journal Paper

Title

Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients

Author(s)

LAO THUAN DUC | Nguyen Minh Trong | Nguyen Dung Huu | HUYEN LE THUY AI | Issue Writer Certificate

Keywords

Mirn155 microRNA

Nasopharyngeal carcinoma

Vietnamese

Abstract

Background: The upregulation of miRNA-155 (miR-155) has been associated with oncogenesis of many human tumors, including Nasopharyngeal carcinoma (NPC). However, the profile of miR-155 in Vietnamese NPC patients has not been investigated. The current study aimed to evaluate the miR-155 expression and assess whether miR-155 is a potential biomarker for diagnosis of NPC in Vietnamese patients. Methods: In current case-control study, total of RNA was isolated from 60 biopsy NPC samples and 60 non-cancerous swab samples were analyzed by Reverse-transcription PCR, qualitative Real-time PCR. Results: The frequency of miR-155 detection were 78. 33%, 15. 0% in NPC and non-cancerous samples (P<0. 05), respectively. The miR-155 expression level was 4. 92 times higher in tumor samples than non-cancerous sample. Conclusion: Taken together, miR-155 in NPC was upregulated. It may serve as a potential biomarker for NPC in the Vietnamese population.

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APA: Copy

LAO, THUAN DUC, Nguyen, Minh Trong, Nguyen, Dung Huu, & HUYEN LE, THUY AI. (2021). Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients. IRANIAN JOURNAL OF PUBLIC HEALTH, 50(8), 1642-1647. SID. https://sid.ir/paper/689711/en

Vancouver: Copy

LAO THUAN DUC, Nguyen Minh Trong, Nguyen Dung Huu, HUYEN LE THUY AI. Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2021;50(8):1642-1647. Available from: https://sid.ir/paper/689711/en

IEEE: Copy

THUAN DUC LAO, Minh Trong Nguyen, Dung Huu Nguyen, and THUY AI HUYEN LE, “Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 50, no. 8, pp. 1642–1647, 2021, [Online]. Available: https://sid.ir/paper/689711/en

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