Investigation of the Antioxidant Activity and Toxicity of Schiff Bases Complex N, Nʹ Di Pirodexil 1, 4 Butadiamin on Breast Cancer Cell Line (MCF7)

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Tabatabayi Zohre Sadat; HOMAYOUNI TABRIZI MASOUD; NEAMATI ALI

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Journal: Journal of Arak University Medical Sciences Year:2019 | Volume:21 | Issue:7 (136) Page(s): 58-67

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Title

Investigation of the Antioxidant Activity and Toxicity of Schiff Bases Complex N, Nʹ Di Pirodexil 1, 4 Butadiamin on Breast Cancer Cell Line (MCF7)

Author(s)

Tabatabayi Zohre Sadat | HOMAYOUNI TABRIZI MASOUD | NEAMATI ALI | Issue Writer Certificate

Keywords

AntioxidantQ2

CancerQ1

Schiff base complex NQ2

Nʹdi pirodexilQ2

Abstract

Background and Aim: Increasing metabolism and production of free radicals in the body are among the factors causing increased oxidative stress, weakened the Antioxidant system, and some diseases, including Cancer. The purpose of this study was to investigate the Antioxidant activity and toxic effect of the Schiff base manganese II compound N, Nʹ di pirodexil 1, 4 butadiamin. Materials and Methods: The Antioxidant capacity of the Schiff base manganese II complex N, Nʹ di pirodexil 1, 4 butadiamin at the concentrations of 62. 5, 125, 250, and 500 μ g/ml was Investigated using the 1. 1-diphenyl-2-picricyl-hydrazyl (DPPH) technique. We also evaluated the toxic effect of the mentioned Schiff bases complex at concentrations of 0, 62. 5, 125, 250 and 500 μ g/ml by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) at 24, 48 and 72 hours on a breast Cancer cell line (MCF7 [Michigan Cancer Foundation-7]). Ethical Considerations: In this study, research ethical principles were considered. Findings: The Antioxidant capacity of Schiff bases manganese II complex N, N di pirodexil 1, 4 butadiamin at the concentration of 500 μ g/ml was 38. 83%. Further, considering the toxic effect of the Schiff bases on the MCF7 cell line, the results showed that IC50 at 24, 48 and 72 hours was about 124, 245 and 470 μ g/ml, respectively. Conclusion: The results obtained from the review of the Antioxidant capacity of the Schiff base manganese II complex N, Nʹ di pirodexil 1, 4 butadiamin compared to (BHA) butylated hydroxyanisole suggest that the compound can be effective in free radical inhibition.

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APA: Copy

Tabatabayi, Zohre Sadat, HOMAYOUNI TABRIZI, MASOUD, & NEAMATI, ALI. (2019). Investigation of the Antioxidant Activity and Toxicity of Schiff Bases Complex N, Nʹ Di Pirodexil 1, 4 Butadiamin on Breast Cancer Cell Line (MCF7). ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(7 (136) ), 58-67. SID. https://sid.ir/paper/68983/en

Vancouver: Copy

Tabatabayi Zohre Sadat, HOMAYOUNI TABRIZI MASOUD, NEAMATI ALI. Investigation of the Antioxidant Activity and Toxicity of Schiff Bases Complex N, Nʹ Di Pirodexil 1, 4 Butadiamin on Breast Cancer Cell Line (MCF7). ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;21(7 (136) ):58-67. Available from: https://sid.ir/paper/68983/en

IEEE: Copy

Zohre Sadat Tabatabayi, MASOUD HOMAYOUNI TABRIZI, and ALI NEAMATI, “Investigation of the Antioxidant Activity and Toxicity of Schiff Bases Complex N, Nʹ Di Pirodexil 1, 4 Butadiamin on Breast Cancer Cell Line (MCF7),” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 7 (136) , pp. 58–67, 2019, [Online]. Available: https://sid.ir/paper/68983/en

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