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Title

MICRODOSE FLARE-UP GONADOTROPIN-RELEASING HORMONE (GNRH) AGONIST VERSUS GNRH ANTAGONIST PROTOCOLS IN POOR OVARIAN RESPONDERS UNDERGOING INTRACYTOPLASMIC SPERM INJECTION

Pages

  163-168

Abstract

 Background: Microdose FLARE-UP GnRH AGONIST and GnRH antAGONIST have become more popular in the management of poor ovarian responders (POR) in recent years; however, the optimal protocol for POR patients undergoingin vitro fertilization has still been a challenge.Methods: In this observational study design, two hundred forty four poor ovarian responders were retrospectively evaluated for their response to GnRH AGONIST protocol (group-1, n=135) or GnRH antAGONIST protocol (group-2, n=109). Clinical pregnancy rate was the primary end point and was compared between the groups. Student t-test, Mann Whitney U test andc2-test were used to compare the groups. The p<0.05 was considered to show a statistically significant result.Results: The mean total gonadotropin doses were 3814±891 IU in group 1 and 3539±877IU in group 2 (p=0.02). The number of metaphase-II oocytes (3.6±2.4 vs. 2.8±1.9, p=0.005) and implantation rates (27.8%vs.18.8%, p=0.04) in group 1 and group 2, respectively were significantly different. The fertilization rate in group 1 and group 2 was 73%vs.68%, respectively (p=0.5) and clinical pregnancy rate was 19.8%vs.14.4%, respectively (p=0.13).Conclusion: The GnRH AGONIST microdose FLARE-UP protocol has favorable outcomes with respect to the number of oocytes retrieved and implantation rate; nevertheless, the clinical pregnancy rate was found to be similar in comparison to GnRH antAGONIST protocol in poor ovarian responders. GnRH antAGONIST protocol appears to be promising with significantly lower gonadotropin requirement and lower treatment cost in poor ovarian responders.

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    APA: Copy

    BOZA, AYSEN, CAKAR, ERBIL, BOZA, BARIS, MURAT, API, KAYATAS, SEMRA, & SOFUOGLU, KENAN. (2016). MICRODOSE FLARE-UP GONADOTROPIN-RELEASING HORMONE (GNRH) AGONIST VERSUS GNRH ANTAGONIST PROTOCOLS IN POOR OVARIAN RESPONDERS UNDERGOING INTRACYTOPLASMIC SPERM INJECTION. JOURNAL OF REPRODUCTION AND INFERTILITY, 17(3), 163-168. SID. https://sid.ir/paper/689884/en

    Vancouver: Copy

    BOZA AYSEN, CAKAR ERBIL, BOZA BARIS, MURAT API, KAYATAS SEMRA, SOFUOGLU KENAN. MICRODOSE FLARE-UP GONADOTROPIN-RELEASING HORMONE (GNRH) AGONIST VERSUS GNRH ANTAGONIST PROTOCOLS IN POOR OVARIAN RESPONDERS UNDERGOING INTRACYTOPLASMIC SPERM INJECTION. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2016;17(3):163-168. Available from: https://sid.ir/paper/689884/en

    IEEE: Copy

    AYSEN BOZA, ERBIL CAKAR, BARIS BOZA, API MURAT, SEMRA KAYATAS, and KENAN SOFUOGLU, “MICRODOSE FLARE-UP GONADOTROPIN-RELEASING HORMONE (GNRH) AGONIST VERSUS GNRH ANTAGONIST PROTOCOLS IN POOR OVARIAN RESPONDERS UNDERGOING INTRACYTOPLASMIC SPERM INJECTION,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 17, no. 3, pp. 163–168, 2016, [Online]. Available: https://sid.ir/paper/689884/en

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