مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

72
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

90
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing

Pages

  120-133

Abstract

 Objective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO). Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days. Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with anti-macrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic erythrocytes to total erythrocytes between treated and negative control, demonstrating the absence of genoToxicity and cytoToxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatoToxicity. Conclusion: Formulations of CDO exerted beneficial effects on the stages of Cutaneous wound healing and are promising options for the treatment of wounds.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Goncalves Dias, Fernanda Gosuen, Freitas Pereira, Lucas de, Furtado, Ricardo Andrade, Magalhaes, Georgia Mode, Miguel, Marina Pacheco, Gosuen Goncalves Dias, Luis Gustavo, Jorge, Adriana Torrecilhas, Santos Honsho, Cristiane dos, Ambrosio, Sergio Ricardo, Bastos, Jairo Kenupp, Carrijo, Micaela Silva, & Tavares, Denise Crispim. (2021). Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(2), 120-133. SID. https://sid.ir/paper/690095/en

    Vancouver: Copy

    Goncalves Dias Fernanda Gosuen, Freitas Pereira Lucas de, Furtado Ricardo Andrade, Magalhaes Georgia Mode, Miguel Marina Pacheco, Gosuen Goncalves Dias Luis Gustavo, Jorge Adriana Torrecilhas, Santos Honsho Cristiane dos, Ambrosio Sergio Ricardo, Bastos Jairo Kenupp, Carrijo Micaela Silva, Tavares Denise Crispim. Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(2):120-133. Available from: https://sid.ir/paper/690095/en

    IEEE: Copy

    Fernanda Gosuen Goncalves Dias, Lucas de Freitas Pereira, Ricardo Andrade Furtado, Georgia Mode Magalhaes, Marina Pacheco Miguel, Luis Gustavo Gosuen Goncalves Dias, Adriana Torrecilhas Jorge, Cristiane dos Santos Honsho, Sergio Ricardo Ambrosio, Jairo Kenupp Bastos, Micaela Silva Carrijo, and Denise Crispim Tavares, “Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 2, pp. 120–133, 2021, [Online]. Available: https://sid.ir/paper/690095/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button