THE EFFECT OF CONSUMING AERIAL PART OF SILYBUM MARIANUM ON BLOOD GLUCOSE AND LIPIDS IN DIABETIC RATS

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ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT; FALAH MOHAMMADI M.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2007 | Volume:10 | Issue:2 (39) Page(s): 31-38

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Title

THE EFFECT OF CONSUMING AERIAL PART OF SILYBUM MARIANUM ON BLOOD GLUCOSE AND LIPIDS IN DIABETIC RATS

Author(s)

ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | FALAH MOHAMMADI M. | Issue Writer Certificate

Keywords

SILYBUM MARIANUMQ3

GLUCOSEQ2

LIPIDQ2

DIABETES MELLITUSQ3

RATQ2

Abstract

Introduction: Use of medicinal plants for decreasing blood GLUCOSE and LIPIDs to normal level is clinically important. In this respect, SILYBUM MARIANUM (SM) is a plant that can lower LIPID peroxidation and LIPIDs in an experimental model of hyperlipidemia. Therefore, the effect of chronic oral administration of this plant on serum GLUCOSE, triglyceride, total cholesterol, and HDL and LDL cholesterol level of diabetic RATs was investigated.Materials and Methods: In this experimental study, female RATs (n=36) were randomly divided into 4 groups, including; control, SM-treated control, diabetic, and SM-treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food (6.25%) for 4 weeks. Serum GLUCOSE, triglyceride, total cholesterol, LDL and HDL cholesterol levels were determined before the intervention, and at 2nd and 4th weeks after the intervention. Data was analyzed using repeated measure ANOVA, One way ANOVA, student and pairt T and Tukey tests.Results: Serum GLUCOSE level in diabetic group was increased in second and 4th weeks after the intervention as compared to one week before that (p<0.001) and SM treated diabetic RATs only had a mild non-significant effect. In addition, triglyceride level in diabetic group increased 4 weeks after the intervention in comparison to related data one week before that (p<0.05) and there was a significant lower level of triglyceride in SM-treated diabetic RATs (p<0.05). Furthermore, a similar significant reduction was obtained for treated-diabetic group as compared to diabetic group regarding serum cholesterol level (p<0.05). On the other hand, HDL- and LDL- cholesterol levels were significantly higher (p<0.05) and lower (p<0.05) in SM-treated diabetic group as compared to untreated diabetic group respectively.Conclusion: Oral chronic administration of SM had no significant hypoglycemic effect and led to appropriate changes in blood LIPID profile.

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APA: Copy

ROUGHANI, M., BALUCHNEJADMOJARAD, TOURANDOKHT, & FALAH MOHAMMADI, M.. (2007). THE EFFECT OF CONSUMING AERIAL PART OF SILYBUM MARIANUM ON BLOOD GLUCOSE AND LIPIDS IN DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 10(2 (39)), 31-38. SID. https://sid.ir/paper/69016/en

Vancouver: Copy

ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT, FALAH MOHAMMADI M.. THE EFFECT OF CONSUMING AERIAL PART OF SILYBUM MARIANUM ON BLOOD GLUCOSE AND LIPIDS IN DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2007;10(2 (39)):31-38. Available from: https://sid.ir/paper/69016/en

IEEE: Copy

M. ROUGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, and M. FALAH MOHAMMADI, “THE EFFECT OF CONSUMING AERIAL PART OF SILYBUM MARIANUM ON BLOOD GLUCOSE AND LIPIDS IN DIABETIC RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 10, no. 2 (39), pp. 31–38, 2007, [Online]. Available: https://sid.ir/paper/69016/en

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