ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF IRIS SONGARICA SCHRENK RHIZOME ETHANOLIC EXTRACT IN MICE

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AHANI ABOLFAZL; HASSANZADEH TAHERI MOHAMMADMEHDI; HOSSEINI MEHRAN; HASSANPOUR FARD MOHAMMAD

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Journal Paper

Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:20 | Issue:8 (125) Page(s): 9-19

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Title

ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF IRIS SONGARICA SCHRENK RHIZOME ETHANOLIC EXTRACT IN MICE

Author(s)

AHANI ABOLFAZL | HASSANZADEH TAHERI MOHAMMADMEHDI | HOSSEINI MEHRAN | HASSANPOUR FARD MOHAMMAD | Issue Writer Certificate

Keywords

ANTIINFLAMMATORY ACTIVITYQ1

ANTINOCICEPTIVE ACTIVITYQ1

IRIS SONGARICA SCHERENKQ1

RHIZOMEQ1

Abstract

Background: The RHIZOME of IRIS SONGARICA SCHERENK has been prescribed as anodyne in Persian traditional medicine system. However, its effects have never been investigated experimentally. Thus, the present study was designed to evaluate the ant inociceptive and anti-inflammatory effects of alcoholic extract of IRIS SONGARICA SCHERENK RHIZOME in mice.Material and Methods: In this experimental study, adult male balb/c mice were used.40 animals were allocated into five equal groups (control, morphine 5mg/kg, the extracts at doses of 100, 200 and 300 mg.kg) and tested for ant inociceptive evaluation via using hot-plate in 30, 60 and 120 minutes after the investigations. Also, the other 36 mice were divided into six equal groups (no-inflammation control, inflammation model, dexamethasone 4 mg/kg and the extracts at doses of 100, 200 and 300 mg.kg) and evaluated for anti-inflammatory activity in xylene induced inflammation model. All the investigations were done via intraperitoneal injection. Data were analyzed using one-way ANOVA or Kruskal-Wallis tests in SPSS.Results: Compared to the control group, the extract at the all doses could increase latency time in hot plate test at 30, 60 and 120 minutes after investigation (p<0.05).This potential was comparable to morphine in the high doses or long time. In addition, the extracts at the all doses exhibited high anti-inflammatory activity which was comparable to dexamethasone (p<0.001).Conclusion: The results of present study clearly showed that IRIS SONGARICA SCHERENK RHIZOME has ant inociceptive and anti-inflammatory activities in mice.

Cites

Ethanolic extract of Iris songarica rhizome attenuates methotrexate-induced liver and kidney damages in rats

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APA: Copy

AHANI, ABOLFAZL, HASSANZADEH TAHERI, MOHAMMADMEHDI, HOSSEINI, MEHRAN, & HASSANPOUR FARD, MOHAMMAD. (2017). ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF IRIS SONGARICA SCHRENK RHIZOME ETHANOLIC EXTRACT IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(8 (125) ), 9-19. SID. https://sid.ir/paper/69034/en

Vancouver: Copy

AHANI ABOLFAZL, HASSANZADEH TAHERI MOHAMMADMEHDI, HOSSEINI MEHRAN, HASSANPOUR FARD MOHAMMAD. ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF IRIS SONGARICA SCHRENK RHIZOME ETHANOLIC EXTRACT IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(8 (125) ):9-19. Available from: https://sid.ir/paper/69034/en

IEEE: Copy

ABOLFAZL AHANI, MOHAMMADMEHDI HASSANZADEH TAHERI, MEHRAN HOSSEINI, and MOHAMMAD HASSANPOUR FARD, “ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF IRIS SONGARICA SCHRENK RHIZOME ETHANOLIC EXTRACT IN MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 8 (125) , pp. 9–19, 2017, [Online]. Available: https://sid.ir/paper/69034/en

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