PADI-4 GENE POLYMORPHISM IN PATIENT WITH RHEUMATOID ARTHRITIS REFERRING TO IMAM REZA HOSPITAL IN MASHHAD

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DELFAN BIRANVAND M.; MAHMOUDI MAHMOUD; RASTIN M.; SHEYKHIAN A.

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Journal: Journal of Arak University Medical Sciences Year:2009 | Volume:12 | Issue:1 (46) Page(s): 41-47

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Title

PADI-4 GENE POLYMORPHISM IN PATIENT WITH RHEUMATOID ARTHRITIS REFERRING TO IMAM REZA HOSPITAL IN MASHHAD

Author(s)

DELFAN BIRANVAND M. | MAHMOUDI MAHMOUD | RASTIN M. | SHEYKHIAN A. | Issue Writer Certificate

Keywords

RHEUMATOID ARTHRITISQ2

POLYMORPHISMQ2

PEPTIDYLARGININE DEIMINASE 4Q3

Abstract

Background: There are citrullin peptides in RHEUMATOID ARTHRITIS (RA) patients that are changed by Peptidyl Arginine Deiminase enzymes (encoded by PADI genes). An association between RA and PADI-4 haplotypes has been reported by researchers. The aim of this study is evaluation of PADI-4 Gene POLYMORPHISM in patient with RHEUMATOID ARTHRITIS referring.Methods and Materials: In this cross-sectional study we extracted the genomic DNAs from the whole blood samples of 50 patients with RA ( on the basis of ACR criteria) referring to Imam Reza hospital in Mashhad and a control group involving 50 healthy khorrasanian participants. DNA genom was extracted with nonenzymatic salting out method. Genotypes were determined by PCR simple sequence specific primers (PCR-SSP). Data were analyzed with Chi-Square and Fisherexact Test.Results: 58% of the patients had genotypes of 1and 2; 38%: 1,4, 2%: 1b,2 ,and 2%: 2,4. In the control group, 72% had genotype 1,2; 22%: 1 and 4, 6%: 1b,2 while none of them had genotype 2,4.Conclusion: There was not any significant relationship between the presence of different PADI-4 genotypes and RA in Khorrasanian population.

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APA: Copy

DELFAN BIRANVAND, M., MAHMOUDI, MAHMOUD, RASTIN, M., & SHEYKHIAN, A.. (2009). PADI-4 GENE POLYMORPHISM IN PATIENT WITH RHEUMATOID ARTHRITIS REFERRING TO IMAM REZA HOSPITAL IN MASHHAD. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 12(1 (46)), 41-47. SID. https://sid.ir/paper/69041/en

Vancouver: Copy

DELFAN BIRANVAND M., MAHMOUDI MAHMOUD, RASTIN M., SHEYKHIAN A.. PADI-4 GENE POLYMORPHISM IN PATIENT WITH RHEUMATOID ARTHRITIS REFERRING TO IMAM REZA HOSPITAL IN MASHHAD. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2009;12(1 (46)):41-47. Available from: https://sid.ir/paper/69041/en

IEEE: Copy

M. DELFAN BIRANVAND, MAHMOUD MAHMOUDI, M. RASTIN, and A. SHEYKHIAN, “PADI-4 GENE POLYMORPHISM IN PATIENT WITH RHEUMATOID ARTHRITIS REFERRING TO IMAM REZA HOSPITAL IN MASHHAD,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 12, no. 1 (46), pp. 41–47, 2009, [Online]. Available: https://sid.ir/paper/69041/en

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