THE COMPARISON EFFECT OF MIDAZOLAM WITH PROPOFOL ON PRE-OPERATIVE ANXIOLYSIS

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MOSHIRI E.; KHALILI MOHAMMAD; YAZDI B.; NARENJI F.; CHOGHAEI M.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2009 | Volume:12 | Issue:1 (46) Page(s): 87-94

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Title

THE COMPARISON EFFECT OF MIDAZOLAM WITH PROPOFOL ON PRE-OPERATIVE ANXIOLYSIS

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Keywords

PROPOFOLQ2

MIDAZOLAMQ2

PREOPERATIVE ANXIETYQ3

ANESTHETIC PREMEDICATIONQ3

Abstract

Background: PREOPERATIVE ANXIETY is a common reaction in patients. Many techniques are used for alleviation of it, such as preoperative visit by the anesthetist, reassurance by a psychologist, and prescription of tranquilizer drugs. In this study we surveyed PROPOFOL compared to MIDAZOLAM on preoperative anxiolysis.Methods and Materials: In randomized controlled double-blind clinical trial, 60 patient swith ASA class I candidates for elective abdominal operations were randomly allocated in 3 equal groups (PROPOFOL, MIDAZOLAM and normal salin). Anxiety was measured with 2 different scales: visual analogue scale (VSA) and clinical global impression (CGI). Pulse rate (PR), blood pressure (BP), respiratory rate (RR), and saturation PO2 (SPO2) were measured before drug administration and 3 times after that in 2.5 min intervals. Results were analyzed with ANNOVA, repeated measures ANNOVA, TUKEY, and X2 tests.Results: There were no differences in demographic variables between groups. Both PROPOFOL and MIDAZOLAM were more effective than placebo in anxiety reduction. Both drugs had equal effect (p>0.05). There was no significant difference in BP, PR, RR and SPO2 between two drugs. Conclusion: Both drugs were the same and more effective than placebo. MIDAZOLAM may be preferred for economical reasons.

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APA: Copy

MOSHIRI, E., KHALILI, MOHAMMAD, YAZDI, B., NARENJI, F., & CHOGHAEI, M.. (2009). THE COMPARISON EFFECT OF MIDAZOLAM WITH PROPOFOL ON PRE-OPERATIVE ANXIOLYSIS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 12(1 (46)), 87-94. SID. https://sid.ir/paper/69049/en

Vancouver: Copy

MOSHIRI E., KHALILI MOHAMMAD, YAZDI B., NARENJI F., CHOGHAEI M.. THE COMPARISON EFFECT OF MIDAZOLAM WITH PROPOFOL ON PRE-OPERATIVE ANXIOLYSIS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2009;12(1 (46)):87-94. Available from: https://sid.ir/paper/69049/en

IEEE: Copy

E. MOSHIRI, MOHAMMAD KHALILI, B. YAZDI, F. NARENJI, and M. CHOGHAEI, “THE COMPARISON EFFECT OF MIDAZOLAM WITH PROPOFOL ON PRE-OPERATIVE ANXIOLYSIS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 12, no. 1 (46), pp. 87–94, 2009, [Online]. Available: https://sid.ir/paper/69049/en

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