THE EFFECT OF HESPERETIN ON SHORT-TERM SPATIAL MEMORY AND PASSIVE AVOIDANCE LEARNING AND MEMORY IN DIABETIC RATS

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ROGHANI MEHRDAD; KHALILI MOHSEN; BALUCHNEJADMOJARAD TOURANDOKHT; HEYDARI AMIN

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2011 | Volume:14 | Issue:1 (54) Page(s): 46-54

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Title

THE EFFECT OF HESPERETIN ON SHORT-TERM SPATIAL MEMORY AND PASSIVE AVOIDANCE LEARNING AND MEMORY IN DIABETIC RATS

Author(s)

ROGHANI MEHRDAD | KHALILI MOHSEN | BALUCHNEJADMOJARAD TOURANDOKHT | HEYDARI AMIN | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ3

HESPERETINQ2

LEARNINGQ3

MEMORYQ2

Abstract

Background: Chronic DIABETES MELLITUS is accompanied with disturbances in LEARNING, MEMORY, and cognitive skills. Noticing the existing evidence regarding the anti-diabetic potential of HESPERETIN, the effect of its chronic administration on LEARNING and MEMORY in diabetic rats was investigated. Materials and Methods: In this experimental study, 40 male Wistar rats were divided into control, HESPERETIN-treated control, diabetic, and HESPERETIN/glibenclamide-treated diabetic groups. For evaluation of LEARNING and MEMORY, initial (IL) and step-through latencies (STL) were determined at the end of the study using passive avoidance test, and the alternation behavior percentage was obtained using Y maze.Results: STL significantly decreased in the diabetic (p<0.01) and HESPERETIN-treated diabetic (p<0.05) groups in comparison to the control group; however, the difference between these two groups was not significant. Alternation percentage in the diabetic group was significantly lower in comparison to the control group (p<0.05), but the HESPERETIN-treated diabetic group revealed a significant difference in comparison to the diabetic group (p<0.05).Conclusion: Although long-term treatment with HESPERETIN does not enhance the capability of retention and recall in diabetic animals on the passive avoidance test, it can improve the short-term spatial MEMORY in diabetic animals.

Cites

A REVIEW ON THE BEHAVIORAL TESTS FOR LEARNING AND MEMORY ASSESSMENTS IN RAT

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APA: Copy

ROGHANI, MEHRDAD, KHALILI, MOHSEN, BALUCHNEJADMOJARAD, TOURANDOKHT, & HEYDARI, AMIN. (2011). THE EFFECT OF HESPERETIN ON SHORT-TERM SPATIAL MEMORY AND PASSIVE AVOIDANCE LEARNING AND MEMORY IN DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 14(1 (54)), 46-54. SID. https://sid.ir/paper/69073/en

Vancouver: Copy

ROGHANI MEHRDAD, KHALILI MOHSEN, BALUCHNEJADMOJARAD TOURANDOKHT, HEYDARI AMIN. THE EFFECT OF HESPERETIN ON SHORT-TERM SPATIAL MEMORY AND PASSIVE AVOIDANCE LEARNING AND MEMORY IN DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2011;14(1 (54)):46-54. Available from: https://sid.ir/paper/69073/en

IEEE: Copy

MEHRDAD ROGHANI, MOHSEN KHALILI, TOURANDOKHT BALUCHNEJADMOJARAD, and AMIN HEYDARI, “THE EFFECT OF HESPERETIN ON SHORT-TERM SPATIAL MEMORY AND PASSIVE AVOIDANCE LEARNING AND MEMORY IN DIABETIC RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 14, no. 1 (54), pp. 46–54, 2011, [Online]. Available: https://sid.ir/paper/69073/en

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