ANTINOCICEPTIVE EFFECT OF CHRONIC ADMINISTRATION OF THE FLAVONOID HESPERETIN IN DIABETIC RATS: BEHAVIORAL EVIDENCE

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ROGHANI MEHRDAD; BALUCHNEJADMOJARAD TOURANDOKHT; AMIRI KHADEJEH

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Journal: Pathobiology Research Year:2010 | Volume:13 | Issue:2 Page(s): 11-21

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Title

ANTINOCICEPTIVE EFFECT OF CHRONIC ADMINISTRATION OF THE FLAVONOID HESPERETIN IN DIABETIC RATS: BEHAVIORAL EVIDENCE

Author(s)

ROGHANI MEHRDAD | BALUCHNEJADMOJARAD TOURANDOKHT | AMIRI KHADEJEH | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ3

FORMALIN TESTQ4

HESPERETINQ2

HOT TAIL IMMERSION TESTQ3

PAINQ3

Abstract

Objective: This study was designed to investigate the antinociceptive effect of chronic administration of the flavonoid HESPERETIN in streptozotocin-diabetic rats using formalin and HOT TAIL IMMERSION TESTs.Materials and Methods: Rats were divided into 5 control groups, HESPERETIN-treated control, diabetic, sodium salicylate (SS) -treated diabetic, and HESPERETIN- and glibenclamide-treated diabetic groups. HESPERETIN (10 mg/kg) was administered i.p. one other day 1 week after diabetes induction for 6 weeks. Finally, thermal PAIN tolerance and nociception were evaluated using hot water tail immersion and FORMALIN TESTs respectively.Results: Diabetic rats exhibited a higher score of PAIN at both phases of the FORMALIN TEST (P<0.05) and HESPERETIN-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (P<0.05). Regarding thermal PAIN tolerance, diabetes significantly reduced tail immersion latency (P<0.01) and HESPERETIN treatment did produce a significant change in this respect (P<0.05).Conclusion: Chronic treatment with HESPERETIN for 6 weeks does mildly increase thermal PAIN tolerance and reduces chemical nociception in an experimental model of DIABETES MELLITUS and this may be considered as an auxiliary treatment for diabetic hyperalgesia.

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APA: Copy

ROGHANI, MEHRDAD, BALUCHNEJADMOJARAD, TOURANDOKHT, & AMIRI, KHADEJEH. (2010). ANTINOCICEPTIVE EFFECT OF CHRONIC ADMINISTRATION OF THE FLAVONOID HESPERETIN IN DIABETIC RATS: BEHAVIORAL EVIDENCE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 13(2), 11-21. SID. https://sid.ir/paper/81200/en

Vancouver: Copy

ROGHANI MEHRDAD, BALUCHNEJADMOJARAD TOURANDOKHT, AMIRI KHADEJEH. ANTINOCICEPTIVE EFFECT OF CHRONIC ADMINISTRATION OF THE FLAVONOID HESPERETIN IN DIABETIC RATS: BEHAVIORAL EVIDENCE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2010;13(2):11-21. Available from: https://sid.ir/paper/81200/en

IEEE: Copy

MEHRDAD ROGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, and KHADEJEH AMIRI, “ANTINOCICEPTIVE EFFECT OF CHRONIC ADMINISTRATION OF THE FLAVONOID HESPERETIN IN DIABETIC RATS: BEHAVIORAL EVIDENCE,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 13, no. 2, pp. 11–21, 2010, [Online]. Available: https://sid.ir/paper/81200/en

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