Improving Tail Flick Analgesic Test by a Custom-Made Restraining Chamber

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AZIZI HOSSEIN; Ahmadi Soleimani S. Mohammad; Ranjbar Slamloo Yadollah; SEMNANIAN SAEED

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Journal Paper

Paper Information

Journal: Pathobiology Research Year:2021 | Volume:24 | Issue:1 Page(s): 7-10

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Title

Improving Tail Flick Analgesic Test by a Custom-Made Restraining Chamber

Author(s)

AZIZI HOSSEIN | Ahmadi Soleimani S. Mohammad | Ranjbar Slamloo Yadollah | SEMNANIAN SAEED | Issue Writer Certificate

Keywords

Tail flick

Restraint

Stress

Analgesia

Rat

Abstract

The Tail flick test is a common method used to evaluate acute pain in animal models. However, there seems to be a technical limitation to the use of this test, deserving a more detailed consideRation. The problem is related to the use of physical Restraints during the test, which in turn exposes the animal to Stress and could therefore undesirably affect the obtained results. In the present report, a newly designed restraining chamber was used to improve the Tail flick test regarding the mentioned limitation. Also, the baseline Tail flick latency in animals undergoing the test using the classic restrainers was compared to that in those restrained by the newly designed chamber. The results indicated that the baseline Tail flick latency was significantly lower in animals restrained by the newly designed box compared to those restrained by the tube-shaped version, which could be attributed to Stress-induced Analgesia. In conclusion, it is recommended that researchers use boxes similar to the custom-made box used in this study to prevent Stress-induced errors when measuring nociceptive thresholds in Rats.

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APA: Copy

AZIZI, HOSSEIN, Ahmadi Soleimani, S. Mohammad, Ranjbar Slamloo, Yadollah, & SEMNANIAN, SAEED. (2021). Improving Tail Flick Analgesic Test by a Custom-Made Restraining Chamber. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 24(1 ), 7-10. SID. https://sid.ir/paper/690732/en

Vancouver: Copy

AZIZI HOSSEIN, Ahmadi Soleimani S. Mohammad, Ranjbar Slamloo Yadollah, SEMNANIAN SAEED. Improving Tail Flick Analgesic Test by a Custom-Made Restraining Chamber. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2021;24(1 ):7-10. Available from: https://sid.ir/paper/690732/en

IEEE: Copy

HOSSEIN AZIZI, S. Mohammad Ahmadi Soleimani, Yadollah Ranjbar Slamloo, and SAEED SEMNANIAN, “Improving Tail Flick Analgesic Test by a Custom-Made Restraining Chamber,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 24, no. 1 , pp. 7–10, 2021, [Online]. Available: https://sid.ir/paper/690732/en

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