RELATIONSHIP BETWEEN CLOPIDOGREL‑RELATED POLYMORPHISMS AND VARIABLE PLATELET REACTIVITY AT 1 YEAR: A COHORT STUDY FROM HAN CHINESE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

XIAODONG WANG; Lai Yan; Luo Yu; Zhang Xumin; Zhou Hua; Ye Zi; Tang Jiani; Liu Xuebo

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:8 Page(s): 0-0

Download Full-Text

View:

200

Download:

151

Cites:

Information Journal Paper

Title

RELATIONSHIP BETWEEN CLOPIDOGREL‑RELATED POLYMORPHISMS AND VARIABLE PLATELET REACTIVITY AT 1 YEAR: A COHORT STUDY FROM HAN CHINESE

Author(s)

Keywords

CLOPIDOGREL

POLYMORPHISM

VERIFYNOW

Abstract

Background: This study was designed to investigate the effect of CLOPIDOGREL-related gene POLYMORPHISMs on platelet reactivity and clinical outcome in Chinese Han patients. Materials and Methods: Three hundred and thirty-six percutaneous coronary intervention - treated patients were recruited and followed for 1 year. Blood samples were collected from all patients for DNA genotyping. The platelet reactivity unit was measured by the VERIFYNOW technique. The CYP2C19*2, CYP2C19*3, CYP2C19*17, ATP-binding cassette subfamily B member 1, ITGB3, CYP2C9*3, CYP2B6*9, and P2Y12 alleles were assessed.Results: The clinical endpoints were related to previous heart disease history (11.90% vs.28.57%, P=0.017), stroke (12.24% vs.16.67%, P=0.039), and diabetes (27.55% vs.52.38%, P=0.047). High on-treatment platelet reactivity (HTPR) was frequent in advanced age (P=0.019), male gender (P=0.016), hypertension (P=0.033), and chronic renal failure (P=0.040). There were more endpoints in the CYP2C19*2 and P2Y12 mutant carriers (76.19% vs.43.20%, P<0.001; 50.00% vs.35.71%, P=0.001, respectively), whereas fewer in the CYP2C19*17 mutant carriers (11.90% vs.56.46%, P=0.001). CYP2C19*2 and P2Y12 POLYMORPHISM manifested HTPR (194.25 ± 45.91 vs.151.38 ± 58.14, P<0.001; 180.33 ± 67.25 vs.161.89 ± 56.49, P=0.008, respectively), whereas CYP2C19*17 mutant improved platelet reactivity (97.17 ± 45.38 vs.169.08 ± 57.15, P=0.003). However, there were no further cardiovascular deaths in endpoint patients.Conclusion: In Han Chinese people of mainland China, CLOPIDOGREL-related gene POLYMORPHISMs are related to variable platelet reactivity after CLOPIDOGREL maintenance dosing, which influences major adverse cardiovascular events, without an effect on cardiac death.

Cites

No record.

References

No record.

Cite

APA: Copy

XIAODONG, WANG, Lai, Yan, Luo, Yu, Zhang, Xumin, Zhou, Hua, Ye, Zi, Tang, Jiani, & Liu, Xuebo. (2016). RELATIONSHIP BETWEEN CLOPIDOGREL?RELATED POLYMORPHISMS AND VARIABLE PLATELET REACTIVITY AT 1 YEAR: A COHORT STUDY FROM HAN CHINESE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(8), 0-0. SID. https://sid.ir/paper/690784/en

Vancouver: Copy

XIAODONG WANG, Lai Yan, Luo Yu, Zhang Xumin, Zhou Hua, Ye Zi, Tang Jiani, Liu Xuebo. RELATIONSHIP BETWEEN CLOPIDOGREL?RELATED POLYMORPHISMS AND VARIABLE PLATELET REACTIVITY AT 1 YEAR: A COHORT STUDY FROM HAN CHINESE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(8):0-0. Available from: https://sid.ir/paper/690784/en

IEEE: Copy

WANG XIAODONG, Yan Lai, Yu Luo, Xumin Zhang, Hua Zhou, Zi Ye, Jiani Tang, and Xuebo Liu, “RELATIONSHIP BETWEEN CLOPIDOGREL?RELATED POLYMORPHISMS AND VARIABLE PLATELET REACTIVITY AT 1 YEAR: A COHORT STUDY FROM HAN CHINESE,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 8, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/690784/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops