ROLE OF MEXZ GENE IN CIPROFLOXACIN RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES IN GUILAN PROVINCE

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RANJI NAJMEH; RAHBAR TAKRAMI SAEID

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Journal Paper

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Journal: Studies in Medical Sciences Year:2017 | Volume:27 | Issue:10 Page(s): 902-913

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Title

ROLE OF MEXZ GENE IN CIPROFLOXACIN RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES IN GUILAN PROVINCE

Author(s)

RANJI NAJMEH | RAHBAR TAKRAMI SAEID | Issue Writer Certificate

Keywords

CIPROFLOXACIN

MEXXY

MEXZ

PSEUDOMONAS AERUGINOSA

Abstract

Background & Aims: PSEUDOMONAS AERUGINOSA is an opportunistic pathogen and one of mortality causes of nosocomial infections specifically in severely burned patients. One of the drug resistant mechanisms in PSEUDOMONAS AERUGINOSA is mutation in negative regulator genes of MEXXY efflux pump system. In this study, the role of MEXZ mutations was investigated in CIPROFLOXACIN resistant development in PSEUDOMONAS AERUGINOSA isolates in Guilan province.Materials & Methods: In this study, 45 strains of PSEUDOMONAS AERUGINOSA isolated from different clinical samples of Rasht and Lahijan hospitals and laboratories between 2014 to 2016 were identified by biochemical tests. The antibiotic resistance and susceptibility of the strains were investigated by Kirby Bauer method and MIC determination. Then PCR-sequencing was performed to assess MEXZ gene mutations in CIPROFLOXACIN resistant strains.Results: From 45 isolates of PSEUDOMONAS AERUGINOSA, all were resistant to cefixime, cephalothin and trimethoprim; whereas 17 isolates were CIPROFLOXACIN resistant. The highest MIC of CIPROFLOXACIN was determined 1024 μg/ml. Also, PCR-sequencing analysis showed that 8 isolates had missense mutations in MEXZ gene such as L111E and R143P.Conclusion: In this study, mutation in MEXZ as negative regulator of MEXXY can be a reason of multidrug resistance in some strains in Guilan province. It appears that MEXZ mutation led to affinity modification in MEXZ protein binding to DNA in some isolates.

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APA: Copy

RANJI, NAJMEH, & RAHBAR TAKRAMI, SAEID. (2017). ROLE OF MEXZ GENE IN CIPROFLOXACIN RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES IN GUILAN PROVINCE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(10), 902-913. SID. https://sid.ir/paper/690817/en

Vancouver: Copy

RANJI NAJMEH, RAHBAR TAKRAMI SAEID. ROLE OF MEXZ GENE IN CIPROFLOXACIN RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES IN GUILAN PROVINCE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2017;27(10):902-913. Available from: https://sid.ir/paper/690817/en

IEEE: Copy

NAJMEH RANJI, and SAEID RAHBAR TAKRAMI, “ROLE OF MEXZ GENE IN CIPROFLOXACIN RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES IN GUILAN PROVINCE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 10, pp. 902–913, 2017, [Online]. Available: https://sid.ir/paper/690817/en

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