INFLUENCE OF OBESTATIN AND SHORT-TERM TREADMILL EXERCISE ON PLASMA ACYL-GHRELIN AND BODYWEIGHT IN WISTAR RAT

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LOTFI ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2016 | Volume:18 | Issue:11 Page(s): 0-0

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Title

INFLUENCE OF OBESTATIN AND SHORT-TERM TREADMILL EXERCISE ON PLASMA ACYL-GHRELIN AND BODYWEIGHT IN WISTAR RAT

Author(s)

LOTFI ALIREZA | Issue Writer Certificate

Keywords

SHORT-TERM EXERCISE

OBESTATIN

GHRELIN

BODYWEIGHT

Abstract

Background: Related reviews reveal that the impact of OBESTATIN (with or without exercise) on the level of GHRELIN has not been investigated. The present study investigates the possible effect of intraperitoneally (IP) -administrated OBESTATIN and SHORT-TERM EXERCISE on serum acyl-ghrelin and body weight in rats.Methods: In present experimental study forty-five male rats weighing 1005 g were divided into five groups; Group 1: control group was normally reared, and did not receive any injections or exercise. Group 2 (placebo) was treated with basal solution (50mLdistilled water). Group 3 was referred to as OBESTATIN group which was subjected to double-injection during the test with OBESTATIN (10g OBESTATIN/ rat). Group 4 was known as treadmill group whichwassubjected to treadmill exercise. Finally, group 5, knownas OBESTATIN /treadmill group (OT), wassubjected to injection with OBESTATIN and treadmill exercise. The exercise groups were trained for 3 weeks (run at 25 m/min for 60 minutes, 5 days/week).The data were analyzed with SPSS software version 16.Results: Twomain parameters include body weight gain and serum acyl-ghrelin was assayed. The results indicate that body weight and GHRELIN level in OBESTATIN and OT groups did not significant changes compared with the control group (P<0.001). However, treadmill group had less GHRELIN level was different significantly from control group (P<0.0001). Also, the treadmill group had the least weight gain (P<0.0001).Conclusions: It was found that whereas short-term treadmill exercise significantly reduces serum acyl-ghrelin, IP-administration of OBESTATIN had no significant impact on serum acyl-ghrelin and final body weight. The short-term treadmill exercise reduced weight gain rate. The results of the study indicated that the combination of OBESTATIN injection and treadmill exercise had no significant impact on the measured variables.

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LOTFI, ALIREZA. (). . , (), -. SID. https://sid.ir/paper/690852/en

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LOTFI ALIREZA. . [Internet]. ;():-. Available from: https://sid.ir/paper/690852/en

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ALIREZA LOTFI, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/690852/en

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