IMPROVEMENT OF KIDNEY APELIN AND APELIN RECEPTOR IN NITRO-L-ARGININE-METHYL ESTER INDUCED RATS

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MAHMOODY S. ALI AKBAR

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Journal Paper

Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2015 | Volume:17 | Issue:2 Page(s): 0-0

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Title

IMPROVEMENT OF KIDNEY APELIN AND APELIN RECEPTOR IN NITRO-L-ARGININE-METHYL ESTER INDUCED RATS

Author(s)

MAHMOODY S. ALI AKBAR | Issue Writer Certificate

Keywords

CHRONIC KIDNEY DISEASE

HYPERTENSION

ADIPOKINES

APELINERGIC SYSTEM

Abstract

Background: We have investigated the effect of 8 weeks aerobic training (AT) and Ferulagummosis supplement (FG) on apelin and apelin receptor (APJ), nitric oxide (NO) andangiotensin converting enzyme (ACE) of hypertensive rats.Materials and Methods: In a experimental study, 50 adult male wistar rats were classifiedinto five groups; 1- AT, 2- FG, 3- combination of aerobic training+Ferula Gummosasupplement (TFG), 4- nitro-L-arginine-methyl ester (L-NAME), 5- shame (control) groups(SH). The rats in the 1 to 4 groups received L-NAME (10 mg/kg, 6 times a week for 8weeks). Also, the 1 and 3 groups experienced the training of 15 to 22 m/min for 25 to 64minutes, 5 times a week for 8 weeks, whereas, the 2 and 3 groups received Ferulagummosis supplement (90 mg/kg, 6 times a week for 8 weeks). However, rats in 5 groupsreceived NaCl solution.Results: At protocols resulted in a significant increase in apelin and APJ as compared tocontrol and L-NAME groups. The TFG protocols resulted in a markedly increase inapelin, APJ and significantly decrease of ACE levels as compared to L-NAME group.Chronically administration of L-NAME resulted increased, ACE, and reduced the levels ofapelin, APJ and NO, as compared to control group.Conclusion: The results in this study show that physical regular activity with and withoutherbal treatment induce amplification in apelin/APJ system and down-regulation bloodpressure in L-NAME induced HYPERTENSION in the rat kidney tissue.

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APA: Copy

MAHMOODY, S. ALI AKBAR. (2015). IMPROVEMENT OF KIDNEY APELIN AND APELIN RECEPTOR IN NITRO-L-ARGININE-METHYL ESTER INDUCED RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(2), 0-0. SID. https://sid.ir/paper/690855/en

Vancouver: Copy

MAHMOODY S. ALI AKBAR. IMPROVEMENT OF KIDNEY APELIN AND APELIN RECEPTOR IN NITRO-L-ARGININE-METHYL ESTER INDUCED RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(2):0-0. Available from: https://sid.ir/paper/690855/en

IEEE: Copy

S. ALI AKBAR MAHMOODY, “IMPROVEMENT OF KIDNEY APELIN AND APELIN RECEPTOR IN NITRO-L-ARGININE-METHYL ESTER INDUCED RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/690855/en

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