THE STEREOLOGIC STUDY OF ONION WATER-ALCOHOL EXTRACT ON DIABETIC RATS, KIDNEYS

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SHARIATZADEH M.A.; SOLEYMANI M.; NOURI M.; DEZFOOLIAN A.; ROODI A.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2005 | Volume:7 | Issue:4 (29) Page(s): 14-21

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Title

THE STEREOLOGIC STUDY OF ONION WATER-ALCOHOL EXTRACT ON DIABETIC RATS, KIDNEYS

Author(s)

Keywords

DIABETES MELLITUSQ3

STEREOLOGYQ3

KIDNEYQ3

ONION EXTRACTQ4

Abstract

Introduction: Diabetes during it's progress can result in nephropathy. Some of it's symptoms are increasing KIDNEY size and weight and it's components. Regarding useful components of onion and it's antioxidant, decreasing stress oxidative and decreasing blood glucose effects, this investigation is designed to study the effect of onion water-alcohol extract in preventing nephropathy and its effect on KIDNEY structure based on STEREOLOGY method. Materials and Methods: Four groups of matured Vistar rats (n=8) were selected randomly (control group, control + extract group, diabetic only group, diabetic + extract group). Diabetes was induced by injecting interperitoneal Sreptozotocin (60mg/kg). The control + extract group and diabetic + extract group were treated by onion-water extract (50mg/rat) every day for four weeks. Then all groups were anesthetized and their left KIDNEY was removed and fixed in Bouin fixative. After histologic passage and H&E dying, using stereologic techniques, qualitative measurement was performed by Cavalier method for cortex, medulla, glomerulus and KIDNEY size. Data analysis was done by SPSS software using one way anova, tukey and paired t test. p<0.05 was considered significant.Results: The primary and secondary weight of rats in only diabetic group and diabetic + extract group was not different, but in control group and control + extract group was significantly different (p<0.05). Medulla, cortex and whole KIDNEY size in only diabetic group in comparison with diabetic + extract group had no difference, but total glomerular size in diabetic only group and diabetic + extract group was significantly different(p<0.001).Conclusion: Experimental induction of diabetes by STZ in a short period showed that ONION EXTRACT can prevent glomerular hypertrophy and increasing KIDNEY weight in diabetic rats, but had no effect on overall KIDNEY size. So the study of ONION EXTRACT effects on KIDNEY structure during a long period is recommended.

Cites

EFFECT OF BARLEY GRAIN (HORDEUM VULGARE L.) CONSUMPTION DURING PREGNANCY IN INDUCED DIABETIC RATS ON KIDNEY HISTOLOGICAL ALTRATIONS OF OFFSPRINGS

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APA: Copy

SHARIATZADEH, M.A., SOLEYMANI, M., NOURI, M., DEZFOOLIAN, A., & ROODI, A.. (2005). THE STEREOLOGIC STUDY OF ONION WATER-ALCOHOL EXTRACT ON DIABETIC RATS, KIDNEYS . ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 7(4 (29)), 14-21. SID. https://sid.ir/paper/69109/en

Vancouver: Copy

SHARIATZADEH M.A., SOLEYMANI M., NOURI M., DEZFOOLIAN A., ROODI A.. THE STEREOLOGIC STUDY OF ONION WATER-ALCOHOL EXTRACT ON DIABETIC RATS, KIDNEYS . ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2005;7(4 (29)):14-21. Available from: https://sid.ir/paper/69109/en

IEEE: Copy

M.A. SHARIATZADEH, M. SOLEYMANI, M. NOURI, A. DEZFOOLIAN, and A. ROODI, “THE STEREOLOGIC STUDY OF ONION WATER-ALCOHOL EXTRACT ON DIABETIC RATS, KIDNEYS ,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 7, no. 4 (29), pp. 14–21, 2005, [Online]. Available: https://sid.ir/paper/69109/en

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