Changes in the Expression of SGO1 and SGO1-AS1 Genes in Colorectal Tumor Tissues, Compared to Healthy Tissues

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Asad Samani Mojtaba; PEYMANI MARYAM

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Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2021 | Volume:24 | Issue:2 (150) Page(s): 168-171

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Information Journal Paper

Title

Changes in the Expression of SGO1 and SGO1-AS1 Genes in Colorectal Tumor Tissues, Compared to Healthy Tissues

Author(s)

Asad Samani Mojtaba | PEYMANI MARYAM | Issue Writer Certificate

Keywords

SGO1 gene

SGO1-AS1 gene

Colorectal cancer

ROC curve

Abstract

Background and Aim The protein encoded by the SGO1 gene is a member of the shugoshin family of proteins and protects the centromere during mitosis. lncRNAs are non-coding RNA with 200 nucleotides lengths, i. e., involved in regulating gene expression. The current study aimed to evaluate the expression of SGO1 and SGO1-AS1 in different stages of disease progression; we also compared their expression pattern in tumor tissues with healthy tissues in Colorectal cancer patients. Methods & Materials In total, 40 tissue samples of patients with Colorectal cancer were reported according to the examination and criteria with the approval of a pathologist. Besides, 40 normal tissues were sampled from a completely healthy part of the intestine of the same patients. After RNA extraction and cDNA synthesis, the Real-time RT-PCR technique was used to evaluate the expression of the desired genes in the study groups. ROC curve analysis was also used to determine the ability of each selected gene to diagnose the disease. Ethical Considerations This study was approved by the Ethics Committee of Shahrekord Azad University (Code: IR. IAU. SHKREC. 1398. 020). Results The obtained data suggested that SGO1 significantly decreased in the Colorectal cancer tumor samples (P<0. 001) and SGO1-AS1 LncRNA significantly increased expression, compared to adjacent healthy tissues. Additionally, in the age group of below 60 years, compared to the age group of over 60 years, SGO1 expression increased and SGO1-AS1 expression decreased. Based on the AUC obtained from the ROC diagram, it was found that the SGO1 gene with AUC=0. 8041 and SGO1-AS1 with AUC=0. 6364 could significantly distinguish a healthy population from patients with Colorectal cancer. Conclusion According to the collected results, SGO1-AS1 and SGO1 were significantly reduced and increased in tumor tissue, respectively; however, only the SGO1 gene was introduced as a good marker for diagnosing Colorectal cancer.

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APA: Copy

Asad Samani, Mojtaba, & PEYMANI, MARYAM. (2021). Changes in the Expression of SGO1 and SGO1-AS1 Genes in Colorectal Tumor Tissues, Compared to Healthy Tissues. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 24(2 (150) ), 168-171. SID. https://sid.ir/paper/691200/en

Vancouver: Copy

Asad Samani Mojtaba, PEYMANI MARYAM. Changes in the Expression of SGO1 and SGO1-AS1 Genes in Colorectal Tumor Tissues, Compared to Healthy Tissues. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2021;24(2 (150) ):168-171. Available from: https://sid.ir/paper/691200/en

IEEE: Copy

Mojtaba Asad Samani, and MARYAM PEYMANI, “Changes in the Expression of SGO1 and SGO1-AS1 Genes in Colorectal Tumor Tissues, Compared to Healthy Tissues,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 24, no. 2 (150) , pp. 168–171, 2021, [Online]. Available: https://sid.ir/paper/691200/en

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