Breast Cancer Cell Lines, HER2/Neu Phenotype, and a Higher Propensity to Reactive Oxygen Species Production

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Mohammadi Abgarmi Zahra; SAHEBGHADAM LOTFI ABBAS; ABROUN SAEID; SOLEIMANI MASOUD; MOHAMMAD GANJI SHAHLA; Baktash Parvaneh; Moradi Arash

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Journal Paper

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Journal: Archives of Breast Cancer Year:2021 | Volume:8 | Issue:2 Page(s): 137-142

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Title

Breast Cancer Cell Lines, HER2/Neu Phenotype, and a Higher Propensity to Reactive Oxygen Species Production

Author(s)

Keywords

HER2/neu

breast cancer cell lines

oxidative stress

Abstract

Background: The reactive oxygen species (ROS) generated in the biological systems play an important role in pathological conditions and specific normal cellular processes, such as signaling pathways and drug sensitivity. Methods: Intracellular ROS was determined using (2'-7'dichlorofluorescin diacetate) DCFH-DA fluorimetric probe, malondialdehyde as lipid peroxidation index detected by the Thiobarbituric acid reactive substances method. Cells' protein carbonyl contents were assessed with 2, 4-Dinitrophenylhydrazine (DNPH) derivatization spectrophotometrically at 360-385 nm. Results: The oxidative stress induces ROS (p˂ 0. 05), MDA (Malondialdehyde) (p˂ 0. 05), and protein carbonylation (p˂ 0. 01) was significantly higher in HER2positive BT-474, SK-BR-3, and MDA-MB-453 compared to the HER2-negative MDA-MB-231 and MCF-7 cell lines. Conclusion: We hypothesized that increased oxidative stress in HER2-positive cell lines is due to the oncogenic function of the HER2 and PI3K/Akt signaling activation, resulting in glycolysis induction. It is assumed that HER2-positive cell lines with high ROS levels are more vulnerable to further damage by increased ROS levels induced by pro-oxidant anticancer agents.

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References

Inhibition of Erbb2 by Trastuzumab Induces Oxidative Stress Markers in HER2 Positive Breast Cancer Cell Lines

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APA: Copy

Mohammadi Abgarmi, Zahra, SAHEBGHADAM LOTFI, ABBAS, ABROUN, SAEID, SOLEIMANI, MASOUD, MOHAMMAD GANJI, SHAHLA, Baktash, Parvaneh, & Moradi, Arash. (2021). Breast Cancer Cell Lines, HER2/Neu Phenotype, and a Higher Propensity to Reactive Oxygen Species Production. ARCHIVES OF BREAST CANCER, 8(2), 137-142. SID. https://sid.ir/paper/691238/en

Vancouver: Copy

Mohammadi Abgarmi Zahra, SAHEBGHADAM LOTFI ABBAS, ABROUN SAEID, SOLEIMANI MASOUD, MOHAMMAD GANJI SHAHLA, Baktash Parvaneh, Moradi Arash. Breast Cancer Cell Lines, HER2/Neu Phenotype, and a Higher Propensity to Reactive Oxygen Species Production. ARCHIVES OF BREAST CANCER[Internet]. 2021;8(2):137-142. Available from: https://sid.ir/paper/691238/en

IEEE: Copy

Zahra Mohammadi Abgarmi, ABBAS SAHEBGHADAM LOTFI, SAEID ABROUN, MASOUD SOLEIMANI, SHAHLA MOHAMMAD GANJI, Parvaneh Baktash, and Arash Moradi, “Breast Cancer Cell Lines, HER2/Neu Phenotype, and a Higher Propensity to Reactive Oxygen Species Production,” ARCHIVES OF BREAST CANCER, vol. 8, no. 2, pp. 137–142, 2021, [Online]. Available: https://sid.ir/paper/691238/en

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