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Information Journal Paper

Title

Cross-Talk of Atherosclerosis and Ischemic Stroke: Dramatic Role of Neutrophils

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  0-0

Abstract

 Context: Current investigations illustrate the increasing prevalence of Atherosclerosis (AS) through the aggravating role of inappropriate lifestyle patterns. Atherosclerosis is the cause of important vascular-related diseases such as Ischemic Stroke (IS). Understanding AS pathophysiology can help reduce the incidence of AS-mediated diseases like Ischemic Stroke. Evidence Acquisition: For this narrative review article, we used the fi ve mega databases of PubMed, Google Scholar, Scopus, Springer, and Science Direct. We searched from 2010 Jan to 2020 Dec and based on keywords and inclusion criteria, 77 articles were enrolled. Results: Based on prior articles on Atherosclerosis and Ischemic Stroke pathophysiology, local and systemic infl ammation is a vigorous factor in both diseasesIndeed, the fundamental infl ammatory pathway involved Atherosclerosis, and Ischemic Stroke is associated with the toll-like receptor 4/myeloid differentiation primary response 88/nuclear factor-kappa B (TLR4/ Myd88/ NF- B) cascade. The functional paw of these intricate mechanisms are pro-infl ammatory mediators, such as interleukin-1 beta (IL-1 ), tumor necrosis factor (TNF- ), and interleukin-18 (IL-18) incite infl ammation. Besides, the essential structures termed infl ammasomes (multi proteins components), and multiplicity of immune and non-immune cells (i. e., Neutrophils, monocytes, platelets, and macrophages) are benefi cial in the induction of infl ammatory microenvironment. Conclusions: Neutrophils could be the most effective cells in the infl ammation-based mechanism in IS and AS. It is clarifi ed that Neutrophils with the recruitment of own vesicles and granules can afford to amplify infl ammatory conditions and be a key cell in AS and IS cross-talk. Therefore, utilizing methods to control Neutrophils-mediated mechanisms could be an effective method for the prevention of AS and IS.

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    APA: Copy

    ESMAEILZADEH, ABDOLREZA, Zare Rafie, Maryam, & Mohammadzadeh, Azita. (2021). Cross-Talk of Atherosclerosis and Ischemic Stroke: Dramatic Role of Neutrophils. ARCHIVES OF NEUROSCIENCE, 8(2), 0-0. SID. https://sid.ir/paper/691364/en

    Vancouver: Copy

    ESMAEILZADEH ABDOLREZA, Zare Rafie Maryam, Mohammadzadeh Azita. Cross-Talk of Atherosclerosis and Ischemic Stroke: Dramatic Role of Neutrophils. ARCHIVES OF NEUROSCIENCE[Internet]. 2021;8(2):0-0. Available from: https://sid.ir/paper/691364/en

    IEEE: Copy

    ABDOLREZA ESMAEILZADEH, Maryam Zare Rafie, and Azita Mohammadzadeh, “Cross-Talk of Atherosclerosis and Ischemic Stroke: Dramatic Role of Neutrophils,” ARCHIVES OF NEUROSCIENCE, vol. 8, no. 2, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/691364/en

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