ASSOCIATION STUDY OF MIR-34B/C GENETIC VARIATION AND ULCERATIVE COLITIS IN GUILAN PROVINCE

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HOSSEINPOUR ZEYNAB; SALEHI ZIVAR; TALESH SASANI SOHEILA; AMINIAN KEYVAN

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Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:1 (118) Page(s): 35-43

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Title

ASSOCIATION STUDY OF MIR-34B/C GENETIC VARIATION AND ULCERATIVE COLITIS IN GUILAN PROVINCE

Author(s)

HOSSEINPOUR ZEYNAB | SALEHI ZIVAR | TALESH SASANI SOHEILA | AMINIAN KEYVAN | Issue Writer Certificate

Keywords

POLYMORPHISMQ2

ULCERATIVE COLITISQ1

MIR34B/CQ1

Abstract

Background: ULCERATIVE COLITIS (UC) is a chronic disease that specifically affects the mucosa of the rectum and colon. The pathogenesis of UC is not well defined, but it is proposed that genetic and environmental factors result in an aberrant immune response to a subset of commensal enteric bacteria.The aim of this study was to investigate whether miR-34b/c rs4938723 T/C POLYMORPHISM is associated with UC risk.Materials and Methods: Blood samples were collected from 50 patients diagnosed with UC and 100 healthy control subjects. Genomic DNA was extracted from peripheral blood. Genetic variation of MIR34B/C was determined by tetra-primers ARMS-PCR (amplification refractory mutation system-polymerase chain reaction). All statistical analyses were conducted using the MedCalc version 12.1.Results: There was a significant difference in genotype and allele distributions between cases and controls. It was observed that the CT heterozygotes had a 2.29-fold increase in risk of UC (OR=2.29, 95%CI=1.08-4.82, p=0.02).Conclusion: It is suggested that the MIR34B/C (rs4938723 T>C) POLYMORPHISM may be associated with the risk of UC. However, larger studies with more patients and controls are needed to confirm this result.

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APA: Copy

HOSSEINPOUR, ZEYNAB, SALEHI, ZIVAR, TALESH SASANI, SOHEILA, & AMINIAN, KEYVAN. (2017). ASSOCIATION STUDY OF MIR-34B/C GENETIC VARIATION AND ULCERATIVE COLITIS IN GUILAN PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(1 (118)), 35-43. SID. https://sid.ir/paper/69143/en

Vancouver: Copy

HOSSEINPOUR ZEYNAB, SALEHI ZIVAR, TALESH SASANI SOHEILA, AMINIAN KEYVAN. ASSOCIATION STUDY OF MIR-34B/C GENETIC VARIATION AND ULCERATIVE COLITIS IN GUILAN PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(1 (118)):35-43. Available from: https://sid.ir/paper/69143/en

IEEE: Copy

ZEYNAB HOSSEINPOUR, ZIVAR SALEHI, SOHEILA TALESH SASANI, and KEYVAN AMINIAN, “ASSOCIATION STUDY OF MIR-34B/C GENETIC VARIATION AND ULCERATIVE COLITIS IN GUILAN PROVINCE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 1 (118), pp. 35–43, 2017, [Online]. Available: https://sid.ir/paper/69143/en

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