SCREENING OF COMMON CHROMOSOMAL DISORDERS IN IRANIAN WOMEN WITH HYDATIDIFORM MOLE USING QF-PCR

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BARARI MASOUMEH; SARI SOYAR; EBRAHIMI AHMAD

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:8 (113) Page(s): 16-25

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Title

SCREENING OF COMMON CHROMOSOMAL DISORDERS IN IRANIAN WOMEN WITH HYDATIDIFORM MOLE USING QF-PCR

Author(s)

BARARI MASOUMEH | SARI SOYAR | EBRAHIMI AHMAD | Issue Writer Certificate

Keywords

CHROMOSOMAL DISORDERSQ1

HYDATIDIFORM MOLEQ1

QF-PCRQ1

Abstract

Background: HYDATIDIFORM MOLE is a benign trophoblastic tumor is made of ectopic pregnancy. Abnormalities in the number or structure of chromosomes are causes of HYDATIDIFORM MOLE common numericaldisorders resulted from proliferating repetitive sequences markers as called STR were studied inthe region of chromosome X, Y, 13, 18 and 21. This study aimed to investigate CHROMOSOMAL DISORDERSprevalent in women with HYDATIDIFORM MOLE, that was performed using QF-PCR techniques.Materials and Methods: In this study, 50 women with HYDATIDIFORM MOLE and 80 healthy womenas controls were selected. For studying the chromosomal abnormalities resulted of proliferating STR, Chromo Quant QF-PCR kit was used. Polymerase chain reaction was performed in PCR machine. Thenelectrophoresis was performed on Genetic Analyzer. Finally, amplified fragment were analyzed by GeneMarker software Statistical analysis was performed using SPSS version 19, and t-test. Data were expressedas mean ± SD. In this test, p<0.05 represents significant level between two groups.Results: In this study, of 50 samples, 8 samples of 47XXY (16%), 40 samples of trisomy 21 (80%) and 2 cases of trisomy 18 (4%) were identified.Conclusion: Anomalies Trisomy 21 (41±1.58) and 47XXY (9.62±1.36) are significantly associatedwith mydatidiform mole disease (p<0.001). The highest percentage of samples with trisomy 21 and47XXY had the disease. So, it indicates that these anomalies have the highest percentage in the disease.

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References

A TEN YEAR REVIEW OF HYDATIDIFORM MOLE IN UNIVERSITY OF CALABAR TEACHING HOSPITAL NIGERIA

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APA: Copy

BARARI, MASOUMEH, SARI, SOYAR, & EBRAHIMI, AHMAD. (2016). SCREENING OF COMMON CHROMOSOMAL DISORDERS IN IRANIAN WOMEN WITH HYDATIDIFORM MOLE USING QF-PCR. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(8 (113)), 16-25. SID. https://sid.ir/paper/69159/en

Vancouver: Copy

BARARI MASOUMEH, SARI SOYAR, EBRAHIMI AHMAD. SCREENING OF COMMON CHROMOSOMAL DISORDERS IN IRANIAN WOMEN WITH HYDATIDIFORM MOLE USING QF-PCR. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(8 (113)):16-25. Available from: https://sid.ir/paper/69159/en

IEEE: Copy

MASOUMEH BARARI, SOYAR SARI, and AHMAD EBRAHIMI, “SCREENING OF COMMON CHROMOSOMAL DISORDERS IN IRANIAN WOMEN WITH HYDATIDIFORM MOLE USING QF-PCR,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 8 (113), pp. 16–25, 2016, [Online]. Available: https://sid.ir/paper/69159/en

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