COMPARISON OF SERUM NESFATIN-1 LEVEL IN TYPE 1 AND 2 DIABETIC RATS

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Eskandari mehrabadi Maryam; SALEMI ZAHRA

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:8 (113) Page(s): 1-7

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Title

COMPARISON OF SERUM NESFATIN-1 LEVEL IN TYPE 1 AND 2 DIABETIC RATS

Author(s)

Eskandari mehrabadi Maryam | SALEMI ZAHRA | Issue Writer Certificate

Keywords

ADIPOKINEQ1

INSULINQ1

STREPTOZOTOCINQ2

Abstract

Background: Diabetes mellitus was induced, when the body doesn’t produce enough INSULIN (diabetes type 1) or is unable to use INSULIN properly (diabetes type 2). In this study, we compare serumnesfatin-1 level in type 1 and 2 diabetic male rats.Materials and Methods: 18 male Wistar rats were divided randomly into 3 groups: control, diabetes type 1, and diabetes type2. Diabetes type 1 was induced by a single injection of STZ (55 mg/kg) and diabetes type 2 was induced by STZ (60 mg/kg) and NA (110 mg/kg). Weight, FBG (fasting bloodglucose), INSULIN, nesfatin-1 were measured in all groups after 6 weeks.Results: Nesfatin-1 levels were increased in diabetic rats compared to the control. Its level inserum was significantly higher in type 2 compared to type 1 diabetic rats. Serum INSULIN and body weightwere reduced significantly in diabetic rats compared to control. Body weight was lower significantly intype 1 than type 2 diabetic rats. FBG was increased significantly in diabetic rats compared to control and itwas higher in type 2 compered to type 1 diabetic rats significantly.Conclusion: The results indicated that nesfatin-1 level in serum of type 2 diabetic rats was higherthan type 1, probably because of higher weight and less destruction of beta cells in type 2 diabetic rats.

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APA: Copy

Eskandari mehrabadi, Maryam, & SALEMI, ZAHRA. (2016). COMPARISON OF SERUM NESFATIN-1 LEVEL IN TYPE 1 AND 2 DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(8 (113)), 1-7. SID. https://sid.ir/paper/69163/en

Vancouver: Copy

Eskandari mehrabadi Maryam, SALEMI ZAHRA. COMPARISON OF SERUM NESFATIN-1 LEVEL IN TYPE 1 AND 2 DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(8 (113)):1-7. Available from: https://sid.ir/paper/69163/en

IEEE: Copy

Maryam Eskandari mehrabadi, and ZAHRA SALEMI, “COMPARISON OF SERUM NESFATIN-1 LEVEL IN TYPE 1 AND 2 DIABETIC RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 8 (113), pp. 1–7, 2016, [Online]. Available: https://sid.ir/paper/69163/en

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