PREVALENCE OF HUMAN PAPILLOMA VIRUS IN SINONASAL PAPILLOMA IN SOUTHERN IRANIAN POPULATION

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VALIBEIGI BEHNAZ; ASHRAF MOHAMAD JAVAD; KERDEGARI NARGES; SAFAI AKBAR; ABEDI ELHAM; KHADEMI BIJAN; AZARPIRA NEGAR

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Journal: JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES) Year:2017 | Volume:18 | Issue:2 Page(s): 143-148

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Title

PREVALENCE OF HUMAN PAPILLOMA VIRUS IN SINONASAL PAPILLOMA IN SOUTHERN IRANIAN POPULATION

Author(s)

Keywords

SINONASAL

PAPILLOMA

CARCINOMA

HUMAN PAPILLOMA VIRUS

HIGH RISK

Abstract

Statement of the Problem: SINONASAL PAPILLOMA (SNP) is a rare benign lesion characterized by high recurrence rate and malignant transformation.Purpose: This study aimed to investigate the prevalence of human PAPILLOMA virus (HPV) infection in these lesions in South of Iran.Materials and Method: In this cross sectional retrospective study, a total of 41 patients, 38 SNP and 3 SNP/Squamous cell CARCINOMA cases, from 2007 to 2014 were studied. Human PAPILLOMA virus (HPV) DNA detection was performed by nested PCR method and positive cases were analyzed for HIGH RISK HPV-16 and HPV-18.Results: HPV was detected in 31.7%; HPV- 16 in 4.9% and HPV 18 was not de-tected at all. Dysplastic epithelium was detected in 53% that was not associated with HPV. Three cases were accompanied with malignant transformation that HPV genome was detected in only one case and none of them were positive for HPV16 /18 genomic DNA.Conclusion: Current research suggests that HPV may be involved in the develop-ment of SNP. But the HIGH RISK HPV is not important in malignant transformation. More studies are needed to elucidate the possible etiologic mechanism between HPV, inverted PAPILLOMA, and squamous cell CARCINOMA.

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APA: Copy

VALIBEIGI, BEHNAZ, ASHRAF, MOHAMAD JAVAD, KERDEGARI, NARGES, SAFAI, AKBAR, ABEDI, ELHAM, KHADEMI, BIJAN, & AZARPIRA, NEGAR. (2017). PREVALENCE OF HUMAN PAPILLOMA VIRUS IN SINONASAL PAPILLOMA IN SOUTHERN IRANIAN POPULATION. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 18(2), 143-148. SID. https://sid.ir/paper/691832/en

Vancouver: Copy

VALIBEIGI BEHNAZ, ASHRAF MOHAMAD JAVAD, KERDEGARI NARGES, SAFAI AKBAR, ABEDI ELHAM, KHADEMI BIJAN, AZARPIRA NEGAR. PREVALENCE OF HUMAN PAPILLOMA VIRUS IN SINONASAL PAPILLOMA IN SOUTHERN IRANIAN POPULATION. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2017;18(2):143-148. Available from: https://sid.ir/paper/691832/en

IEEE: Copy

BEHNAZ VALIBEIGI, MOHAMAD JAVAD ASHRAF, NARGES KERDEGARI, AKBAR SAFAI, ELHAM ABEDI, BIJAN KHADEMI, and NEGAR AZARPIRA, “PREVALENCE OF HUMAN PAPILLOMA VIRUS IN SINONASAL PAPILLOMA IN SOUTHERN IRANIAN POPULATION,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 18, no. 2, pp. 143–148, 2017, [Online]. Available: https://sid.ir/paper/691832/en

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