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Information Journal Paper

Title

The Effect of Recombinant Human Follicle-Stimulating Hormone on Sperm DNA Fragmentation and Sperm Parameters in Oligozoospermic Infertile Men

Pages

  55-61

Abstract

 Background: One of the main causes of male infertility is the negative effects of Oxidative stress. Follicle-Stimulating Hormone (FSH) plays an essential role in spermatogenesis, as well as in the maintenance of sperm DNA integrity. This study aimed to determine whether the Recombinant human follicle-stimulating hormone (rhFSH) treatment of sperm parameters could positively affect sperm DNA and oxidative DNA fragmentation in oligozoospermic infertile men. Materials and Methods: This interventional study was carried out on a sample of 50 oligozoospermic infertile men. To this end, sperm DNA fragmentation and ROS, as an Oxidative stress marker, were measured before and after treatment with rhFSH sperm parameters. Results: The sperm parameters (concentration, mobility, and morphology) were significantly different in the oligozoospermic infertile patients before and after the rhFSH treatment (P<0. 05). Moreover, sperm DNA fragmentation had a significant decrease in patients after the FSH treatment (P<0. 05). Besides, the ROS level in sperm and the Malondialdehyde level of seminal plasma significantly decreased after the treatment (P<0. 05). Conclusion: Treatment with rhFSH significantly improved sperm parameters. Furthermore, the treatment led to a significant reduction of sperm DNA fragmentation and Oxidative stress in the oligozoospermic infertile patients. Similarly, the Malondialdehyde concentration markedly decreased in correlation with DNA fragmentation after the rhFSH treatment.

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    Cite

    APA: Copy

    Verdi, Atefeh, Sahrae, Seyedeh Saeideh, Asa, Elham, Jannatifar, Rahil, & Masaeimanesh, Mohamad Bagher. (2020). The Effect of Recombinant Human Follicle-Stimulating Hormone on Sperm DNA Fragmentation and Sperm Parameters in Oligozoospermic Infertile Men. RESEARCH IN MOLECULAR MEDICINE, 8(2), 55-61. SID. https://sid.ir/paper/691996/en

    Vancouver: Copy

    Verdi Atefeh, Sahrae Seyedeh Saeideh, Asa Elham, Jannatifar Rahil, Masaeimanesh Mohamad Bagher. The Effect of Recombinant Human Follicle-Stimulating Hormone on Sperm DNA Fragmentation and Sperm Parameters in Oligozoospermic Infertile Men. RESEARCH IN MOLECULAR MEDICINE[Internet]. 2020;8(2):55-61. Available from: https://sid.ir/paper/691996/en

    IEEE: Copy

    Atefeh Verdi, Seyedeh Saeideh Sahrae, Elham Asa, Rahil Jannatifar, and Mohamad Bagher Masaeimanesh, “The Effect of Recombinant Human Follicle-Stimulating Hormone on Sperm DNA Fragmentation and Sperm Parameters in Oligozoospermic Infertile Men,” RESEARCH IN MOLECULAR MEDICINE, vol. 8, no. 2, pp. 55–61, 2020, [Online]. Available: https://sid.ir/paper/691996/en

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