Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration

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SOHEILI ZAHRA SOHEILA; AHMADIEH HAMID; MORADIAN SIAMAK; SAMIEE SHAHRAM; DAFTARIAN NARSIS; KHEITAN SAMIRA; D.Alipour Shamila; BAGHERI ABOUZAR; AZIZI SEYED GHADER

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Journal: Research in Molecular Medicine Year:2021 | Volume:9 | Issue:1 Page(s): 61-69

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Title

Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration

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Keywords

Age-related macular degeneration

Complement factor H

Single nucleotide polymorphisms

Exon10

Intron 9

Abstract

Background: Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly. Although it has been shown that Y402H polymorphism in the CFH gene was strongly associated with AMD in the Iranian population, there were no data on other Single nucleotide polymorphisms (SNPs), which have the most significant association with AMD. This study aimed to investigate hot point regions in exon 10 and Intron 9. Materials and Methods: One hundred and sixty-six AMD patients and 69 controls were recruited. Their blood was collected in the tubes containing EDTA. Then, DNA was extracted from the blood, and its quality was evaluated. Primers were designed for Intron 9 and Exon10 sequencing. A viral polymorphisms analysis software named CEQ was used for the analysis of putative polymorphisms. Results: We noticed three polymorphisms in study cases: rs7535263 and C66379A in Intron 9 and rs2274700 in exon 10. Based on the McNamara’ s test (rs7535263 and rs2274700) and the Phi and Cramer’ s test (C66379A), a significant difference was found between the control and patient groups regarding rs7535263 and rs2274700 polymorphisms. Conclusion: We found a synonymous or silent mutation, A473A, rs2274700 in exon 10 in 85% of patients. From two intronic SNPs, just rs7535263 showed association with the disease in studied patients living in Gilan Province, Iran. Although no significant relationship was found between controls and patients regarding the C66379A allele, it would be important that no other sources have reported C66379A polymorphism in AMD yet.

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APA: Copy

SOHEILI, ZAHRA SOHEILA, AHMADIEH, HAMID, MORADIAN, SIAMAK, SAMIEE, SHAHRAM, DAFTARIAN, NARSIS, KHEITAN, SAMIRA, D.Alipour, Shamila, BAGHERI, ABOUZAR, & AZIZI, SEYED GHADER. (2021). Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration. RESEARCH IN MOLECULAR MEDICINE, 9(1), 61-69. SID. https://sid.ir/paper/692015/en

Vancouver: Copy

SOHEILI ZAHRA SOHEILA, AHMADIEH HAMID, MORADIAN SIAMAK, SAMIEE SHAHRAM, DAFTARIAN NARSIS, KHEITAN SAMIRA, D.Alipour Shamila, BAGHERI ABOUZAR, AZIZI SEYED GHADER. Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration. RESEARCH IN MOLECULAR MEDICINE[Internet]. 2021;9(1):61-69. Available from: https://sid.ir/paper/692015/en

IEEE: Copy

ZAHRA SOHEILA SOHEILI, HAMID AHMADIEH, SIAMAK MORADIAN, SHAHRAM SAMIEE, NARSIS DAFTARIAN, SAMIRA KHEITAN, Shamila D.Alipour, ABOUZAR BAGHERI, and SEYED GHADER AZIZI, “Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration,” RESEARCH IN MOLECULAR MEDICINE, vol. 9, no. 1, pp. 61–69, 2021, [Online]. Available: https://sid.ir/paper/692015/en

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