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Information Journal Paper

Title

METHOXYAMINE ENHANCES 5-FLUOROURACIL-INDUCED RADIOSENSITIZATION IN COLON CANCER CELL LINE HT29

Pages

  283-291

Abstract

 Objective: This study intended to observe the effects of METHOXYAMINE (Mx) on cytotoxic effects and DNA damage caused by 5-FLUOROURACIL (5-FU) in combination with gamma RADIATION in a human COLON CANCER cell line, HT29.Materials and Methods: In this experimental study, HT29 cells were cultured as a monolayer and treated with different concentrations of 5-FU along with 1 mM Mx for 24 hours. Next, the cells were irradiated with 2 Gy gamma RADIATION. After the treatments, we assessed for DNA damage, cytotoxicity, and viability by alkaline comet, clonogenic survival, and trypan blue dye exclusion assays.Results: Cytotoxicity and DNA damage increased with increasing 5-FU concentration. The 1 mM Mx concentration had no significant effect on cytotoxicity and DNA damage from 5-FU; however, it increased the cytotoxic and genotoxic effects of different concentrations of 5-FU when used in combination with 2 Gy gamma RADIATION.Conclusion: Mx combined with 5-FU enhanced the radiosensitivity of COLON CANCER cells.

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    APA: Copy

    KHOEI, SAMIDEH, POORABDOLLAHI, ROGHAYEH, MOSTAAR, AHMAD, & FAEGHI, FARIBORZ. (2017). METHOXYAMINE ENHANCES 5-FLUOROURACIL-INDUCED RADIOSENSITIZATION IN COLON CANCER CELL LINE HT29. CELL JOURNAL (YAKHTEH), 19(2), 283-291. SID. https://sid.ir/paper/692523/en

    Vancouver: Copy

    KHOEI SAMIDEH, POORABDOLLAHI ROGHAYEH, MOSTAAR AHMAD, FAEGHI FARIBORZ. METHOXYAMINE ENHANCES 5-FLUOROURACIL-INDUCED RADIOSENSITIZATION IN COLON CANCER CELL LINE HT29. CELL JOURNAL (YAKHTEH)[Internet]. 2017;19(2):283-291. Available from: https://sid.ir/paper/692523/en

    IEEE: Copy

    SAMIDEH KHOEI, ROGHAYEH POORABDOLLAHI, AHMAD MOSTAAR, and FARIBORZ FAEGHI, “METHOXYAMINE ENHANCES 5-FLUOROURACIL-INDUCED RADIOSENSITIZATION IN COLON CANCER CELL LINE HT29,” CELL JOURNAL (YAKHTEH), vol. 19, no. 2, pp. 283–291, 2017, [Online]. Available: https://sid.ir/paper/692523/en

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