EVALUATION OF E492 MICROCIN GENE PRESENCE IN KLEBSIELLA PNEUMONIA COLLECTED FROM PATIENTS REGISTERED TO EDUCATIONAL HOSPITALS OF ISFAHAN

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NASR ESFAHANI MARYAM; AHADI ALI MOHAMMAD; AYAT HODA; NAYERI HASHEM

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Journal Paper

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Journal: Zahedan Journal of Research in Medical Sciences Year:2017 | Volume:19 | Issue:1 Page(s): 0-0

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Title

EVALUATION OF E492 MICROCIN GENE PRESENCE IN KLEBSIELLA PNEUMONIA COLLECTED FROM PATIENTS REGISTERED TO EDUCATIONAL HOSPITALS OF ISFAHAN

Author(s)

NASR ESFAHANI MARYAM | AHADI ALI MOHAMMAD | AYAT HODA | NAYERI HASHEM | Issue Writer Certificate

Keywords

MICROCIN E492

BACTERIOCIN

KLEBSIELLA PNEUMONIAE

Abstract

Background: MICROCIN E492 is a low molecular weight channel-forming microbial toxin that is produced by some KLEBSIELLA PNEUMONIAEstrains. This peptide is active in some strains of Enterobacteriaceae family, and it has different applications in medicine.Objectives: The present descriptive analytical study was carried out to determine the presence of KLEBSIELLA PNEUMONIAE with geneencoding MICROCIN E492 in clinical specimens isolated from patients registered in two hospitals in Isfahan, Iran.Methods: In this interventional-descriptive study, 45 clinical specimens including 20 urine clinical specimens, 10 respiratory tractclinical specimens and 15 burn wounds specimens were selected from Al-Zahra and Imam Musa Kazem hospitals in Isfahan duringthe year 2013. TotalDNAwas extracted from clinical specimens and hot start PCR was optimized using specific primers for the amplificationof the complete sequence of E492 gene. Fidelity of PCR products was confirmed by direct sequencing. Homology analysiswas performed by application of BLAST serve. The data were analyzed with Chromasv2.1.1 software.Results: In forty-five collected clinical specimens (20 urine clinical specimens, 10 respiratory tractclinical specimens and 15 burnwounds specimens), 20 samples (44.4%) were screened with KLEBSIELLA PNEUMONIAE contamination. PCR analysis was showed presenceof E492 gene in 40% (8 samples) of contaminated clinical specimens.Conclusions: About 40% of the clinical specimens collected from Isfahan hospitals contaminated with KLEBSIELLA PNEUMONIAE hadMICROCIN E492 gene. These types of microcins are low molecular weight antibiotic peptides produced by Enterobacteriaceae with awide range of antibacterial activity against Gram-negative bacteria. This property can be useful for antibacterial trials. Existence ofmicrocin gene in Enterobacteriaceae can develop them into a dominant microbial flora in human body internal environment.

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APA: Copy

NASR ESFAHANI, MARYAM, AHADI, ALI MOHAMMAD, AYAT, HODA, & NAYERI, HASHEM. (2017). EVALUATION OF E492 MICROCIN GENE PRESENCE IN KLEBSIELLA PNEUMONIA COLLECTED FROM PATIENTS REGISTERED TO EDUCATIONAL HOSPITALS OF ISFAHAN. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 19(1), 0-0. SID. https://sid.ir/paper/692534/en

Vancouver: Copy

NASR ESFAHANI MARYAM, AHADI ALI MOHAMMAD, AYAT HODA, NAYERI HASHEM. EVALUATION OF E492 MICROCIN GENE PRESENCE IN KLEBSIELLA PNEUMONIA COLLECTED FROM PATIENTS REGISTERED TO EDUCATIONAL HOSPITALS OF ISFAHAN. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2017;19(1):0-0. Available from: https://sid.ir/paper/692534/en

IEEE: Copy

MARYAM NASR ESFAHANI, ALI MOHAMMAD AHADI, HODA AYAT, and HASHEM NAYERI, “EVALUATION OF E492 MICROCIN GENE PRESENCE IN KLEBSIELLA PNEUMONIA COLLECTED FROM PATIENTS REGISTERED TO EDUCATIONAL HOSPITALS OF ISFAHAN,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 19, no. 1, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/692534/en

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