MIR-92A PROMOTES HEPATOCELLULAR CARCINOMA CELLS PROLIFERATION AND INVASION BY FOXA2 TARGETING

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WANG LIANG; WU JINHONG; XIE CHANGAO

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:7 Page(s): 783-790

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Title

MIR-92A PROMOTES HEPATOCELLULAR CARCINOMA CELLS PROLIFERATION AND INVASION BY FOXA2 TARGETING

Author(s)

WANG LIANG | WU JINHONG | XIE CHANGAO | Issue Writer Certificate

Keywords

FOXA2

HEPATOCELLULAR CARCINOMA

INVASION

MIR-92A

PROLIFERATION

Abstract

Objective(s): MicroRNAs (miRNAs) are considered as powerful, post-transcriptional regulators of gene expression in HEPATOCELLULAR CARCINOMA cells (HCC). However, the function of MIR-92A is still unclear in HCC.Materials and Methods: Expression of MIR-92A in human HCC cell lines was evaluated using qRT-PCR. MTT assay and transwell assay were used to examine the function of MIR-92A in HepG2 and Huh7 cells. Bioinformatic analyses and luciferase reporter assays were used to validate FOXA2 as a direct target gene of MIR-92A. Consistently, the biological outcome of MIR-92A on regulating FOXA2 was examined by PROLIFERATION and INVASION analysis in vitro.Results: Here, we detected the higher expression of MIR-92A in human HCC cell lines, such as HepG2, Huh7 and Hep3B, compared with the normal human hepatocyte L02 cells. Overexpression of MIR-92A significantly increased cell growth and INVASION ability, while the knockdown of MIR-92A could remarkably inhibit the growth and INVASION possibility. We identified that MIR-92A has specific targeting sites in the 3' -UTR of the FOXA2. By overexpressing MIR-92A in HepG2 cells or Huh7 cells, the expression of FOXA2 was remarkably repressed.Conclusion: We demonstrated that MIR-92A may play a critical role in HCC PROLIFERATION and INVASION and may serve as a novel therapeutic target by the repression of FOXA2.

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APA: Copy

WANG, LIANG, WU, JINHONG, & XIE, CHANGAO. (2017). MIR-92A PROMOTES HEPATOCELLULAR CARCINOMA CELLS PROLIFERATION AND INVASION BY FOXA2 TARGETING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(7), 783-790. SID. https://sid.ir/paper/692598/en

Vancouver: Copy

WANG LIANG, WU JINHONG, XIE CHANGAO. MIR-92A PROMOTES HEPATOCELLULAR CARCINOMA CELLS PROLIFERATION AND INVASION BY FOXA2 TARGETING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(7):783-790. Available from: https://sid.ir/paper/692598/en

IEEE: Copy

LIANG WANG, JINHONG WU, and CHANGAO XIE, “MIR-92A PROMOTES HEPATOCELLULAR CARCINOMA CELLS PROLIFERATION AND INVASION BY FOXA2 TARGETING,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 7, pp. 783–790, 2017, [Online]. Available: https://sid.ir/paper/692598/en

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