FREQUENCY OF BAP AND CPAA VIRULENCE GENES IN DRUG RESISTANT CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII AND THEIR ROLE IN BIOFILM FORMATION

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FALLAH AREZOO; AHANGARZADEH REZAEE MOHAMMAD; HASANI ALKA; SOROUSH BARHAGHI MOHAMMAD HOSSEIN; SAMADI KAFIL HOSSEIN

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:8 Page(s): 849-855

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Title

FREQUENCY OF BAP AND CPAA VIRULENCE GENES IN DRUG RESISTANT CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII AND THEIR ROLE IN BIOFILM FORMATION

Author(s)

Keywords

ACINETOBACTER BAUMANNII

ANTIBIOTIC RESISTANCE

BIOFILM

BAP

CPAA

Abstract

Objective(s): ACINETOBACTER BAUMANNII has a high propensity to form BIOFILM and frequently causes medical device-related infections with multiple-drug-resistance in hospitals. The aim of this work is to study antimicrobial resistance and the role of BAP and cpa A genes in BIOFILM formation by A. baumannii to understand how this pathogen persists in the hospital environment.Materials and Methods: The ANTIBIOTIC RESISTANCE profile and in vitro BIOFILM-forming ability of one hundred clinical isolates of A. baumannii was evaluated by disc diffusion and crystal-violet staining methods, respectively. Isolates were tested for the presence of BAP and CPAA genes.Results: The isolates were highly resistant to cefepime, third-generation cephalosporins, ciprofloxacin, cotrimoxazole, aminoglycosides and carbapenems. Moreover, four isolates were resistant to colistin. Quantification of BIOFILM showed that 43% of the isolates were strong BIOFILM-producer. Furthermore, 32% of the isolates exhibited moderate BIOFILM-formation and showed initial binding activity. Frequency of BAP and CPAA were determined 92% and 36%, respectively.Conclusion: There was strong association between the presence of BAP gene and BIOFILM formation by A. baumannii isolates (P=0.003). In addition, multidrug resistant isolates produced stronger BIOFILM than other isolates (P=0.0001). These results indicate importance of BIOFILM in resistance of isolates and effect of presence of BAP gene in BIOFILM formation by A. baumannii strains.

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APA: Copy

FALLAH, AREZOO, AHANGARZADEH REZAEE, MOHAMMAD, HASANI, ALKA, SOROUSH BARHAGHI, MOHAMMAD HOSSEIN, & SAMADI KAFIL, HOSSEIN. (2017). FREQUENCY OF BAP AND CPAA VIRULENCE GENES IN DRUG RESISTANT CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII AND THEIR ROLE IN BIOFILM FORMATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(8), 849-855. SID. https://sid.ir/paper/692599/en

Vancouver: Copy

FALLAH AREZOO, AHANGARZADEH REZAEE MOHAMMAD, HASANI ALKA, SOROUSH BARHAGHI MOHAMMAD HOSSEIN, SAMADI KAFIL HOSSEIN. FREQUENCY OF BAP AND CPAA VIRULENCE GENES IN DRUG RESISTANT CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII AND THEIR ROLE IN BIOFILM FORMATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(8):849-855. Available from: https://sid.ir/paper/692599/en

IEEE: Copy

AREZOO FALLAH, MOHAMMAD AHANGARZADEH REZAEE, ALKA HASANI, MOHAMMAD HOSSEIN SOROUSH BARHAGHI, and HOSSEIN SAMADI KAFIL, “FREQUENCY OF BAP AND CPAA VIRULENCE GENES IN DRUG RESISTANT CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII AND THEIR ROLE IN BIOFILM FORMATION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 8, pp. 849–855, 2017, [Online]. Available: https://sid.ir/paper/692599/en

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