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Title

Methylation Status of miR-200b Promoter in Colorectal Polyp and Adenocarcinoma Tissues

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Abstract

 Background: Aberrant DNA Methylation is a common molecular feature in Colorectal cancer (CRC). HyperMethylation of miR-200b promoter, as an epigenetic factor, is involved in CRC tumorigenesis. The Methylation status of miR-200b has been examined in CRC and adjacent normal tissues. Objectives: This study aimed to investigate miR-200b Methylation in a series of colorectal adenomatous Polyps, hyperplastic Polyps, and adenocarcinoma tissues as precursors of CRC in the Iranian population for the first time. Methods: In this cross-sectional study (2017-2018), the Methylation status of the miR-200b promoter was investigated on 131 fresh samples, including adenocarcinoma specimens (n=30), tumor-adjacent normal tissues (n=17), primary lesions (n=78; 55 adenomatous Polyps and 23 hyperplastic Polyps) and healthy individuals (n=6) using Methylation-specific polymerase chain reaction. Results: Methylation of miR-200b was detected in adenocarcinoma samples (86%) and adenomatous Polyps (85%); however, most of the hyperplastic Polyps were unmethylated (69. 6%). Neither control individuals nor tumor-adjacent normal tissues exhibited Methylation in the miR-200b promoter. Aberrant Methylation of miR-200b was significantly more common in tumor tissues and adenomatous Polyps than in hyperplastic Polyps (P<0. 0001) and tumor-adjacent normal samples (P<0. 0001). Conclusion: The Methylation status of the miR-200b promoter was significantly altered during CRC development and may be identified as an indicative biomarker for the early detection of the disease.

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    APA: Copy

    Savabkar, Sanaz, IRANI, SHIVA, ALEBOUYEH, MASOUD, MIRFAKHRAIE, REZA, NAZEMALHOSSEINI MOJARAD, EHSAN, ZALI, MOHAMMAD REZA, & ASADZADEH AGHDAEI, HAMID. (2021). Methylation Status of miR-200b Promoter in Colorectal Polyp and Adenocarcinoma Tissues. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 23(4), 0-0. SID. https://sid.ir/paper/693130/en

    Vancouver: Copy

    Savabkar Sanaz, IRANI SHIVA, ALEBOUYEH MASOUD, MIRFAKHRAIE REZA, NAZEMALHOSSEINI MOJARAD EHSAN, ZALI MOHAMMAD REZA, ASADZADEH AGHDAEI HAMID. Methylation Status of miR-200b Promoter in Colorectal Polyp and Adenocarcinoma Tissues. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2021;23(4):0-0. Available from: https://sid.ir/paper/693130/en

    IEEE: Copy

    Sanaz Savabkar, SHIVA IRANI, MASOUD ALEBOUYEH, REZA MIRFAKHRAIE, EHSAN NAZEMALHOSSEINI MOJARAD, MOHAMMAD REZA ZALI, and HAMID ASADZADEH AGHDAEI, “Methylation Status of miR-200b Promoter in Colorectal Polyp and Adenocarcinoma Tissues,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 23, no. 4, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/693130/en

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