Moderate Aerobic Training Inhibits Middle-Aged Induced Cardiac Calcineurin-NFAT Signaling by Improving TGF-ß , NPR-A, SERCA2, and TRPC6 in Wistar Rats

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BAGHAIEE BEHROUZ; BAYATMAKOO ROSHANAK; KARIMI POURAN; Pescatello Linda Shannon

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Journal: Cell Journal (Yakhteh) Year:2021 | Volume:23 | Issue:7 Page(s): 756-762

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Title

Moderate Aerobic Training Inhibits Middle-Aged Induced Cardiac Calcineurin-NFAT Signaling by Improving TGF-ß , NPR-A, SERCA2, and TRPC6 in Wistar Rats

Author(s)

BAGHAIEE BEHROUZ | BAYATMAKOO ROSHANAK | KARIMI POURAN | Pescatello Linda Shannon | Issue Writer Certificate

Keywords

NPR-A

SERCA

TGF-β

TRPC6

Abstract

Objective: The purpose of this study was to investigate the effect of moderate-intensity training on the calcineurin/ nuclear factor of activated t-cells (NFAT) pathway and factors affecting it in the middle-age Wistar rats. Materials and Methods: In this experimental study, 40 young (n=10, 4-month-old) and middle-aged (n=30, 13-15 months old) Wistar rats were included in this experimental study. All young and 10 middle-aged rats did not training and served as a control comparision; while the remaining 20 middle-aged rats were trained at moderate intensity for 4-weeks (n=10) or 8-weeks (n=10) on a treadmill (speed: 16 m/minutes, slope: 0%, distance: 830 m, duration: 54 minutes). Results: Calcineurin tissue expression was increased in the middle-aged control rats compared to the young control rats (P=0. 001). Expression of sarco/endoplasmic reticulum Ca2+-ATPase (SERC2A), natriuretic peptide receptor-A (NPR-A), phospholamban (PLB), plasma membrane Ca2+ ATPase (PMCA4b), and p-AKT was significantly decreased in the heart tissue of middle-aged control compared to the young control rats (P=0. 001). Furthermore, transforming growth factor beta (TGF-β ), including transient receptor potential canonical 6 (TRPC6), were up-regulated in the heart tissue of middle-aged control compared to the young control rats (P=0. 001). However, aerobic training inhibited this pathway and reversed all changes in the trained middle-aged rats. Conclusion: Aerobic training effectively inhibited the calcineurin/NFATc pathway and modulated intracellular Ca2+ levels at least partially by restoring NPR-A, SERCA2, p-PLB, and p-AKT, and decreasing TRPC6 and TGF-β levels.

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APA: Copy

BAGHAIEE, BEHROUZ, BAYATMAKOO, ROSHANAK, KARIMI, POURAN, & Pescatello, Linda Shannon. (2021). Moderate Aerobic Training Inhibits Middle-Aged Induced Cardiac Calcineurin-NFAT Signaling by Improving TGF-ß , NPR-A, SERCA2, and TRPC6 in Wistar Rats. CELL JOURNAL (YAKHTEH), 23(7), 756-762. SID. https://sid.ir/paper/693279/en

Vancouver: Copy

BAGHAIEE BEHROUZ, BAYATMAKOO ROSHANAK, KARIMI POURAN, Pescatello Linda Shannon. Moderate Aerobic Training Inhibits Middle-Aged Induced Cardiac Calcineurin-NFAT Signaling by Improving TGF-ß , NPR-A, SERCA2, and TRPC6 in Wistar Rats. CELL JOURNAL (YAKHTEH)[Internet]. 2021;23(7):756-762. Available from: https://sid.ir/paper/693279/en

IEEE: Copy

BEHROUZ BAGHAIEE, ROSHANAK BAYATMAKOO, POURAN KARIMI, and Linda Shannon Pescatello, “Moderate Aerobic Training Inhibits Middle-Aged Induced Cardiac Calcineurin-NFAT Signaling by Improving TGF-ß , NPR-A, SERCA2, and TRPC6 in Wistar Rats,” CELL JOURNAL (YAKHTEH), vol. 23, no. 7, pp. 756–762, 2021, [Online]. Available: https://sid.ir/paper/693279/en

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