The effect of aerobic exercise with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats

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KAZEMIPOUR M.; Matin Homaie H.; FARZANEGI P.

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Journal: Feyz Medical Sciences Journal Year:2022 | Volume:26 | Issue:5 Page(s): 521-529

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Information Journal Paper

Title

The effect of aerobic exercise with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats

Author(s)

KAZEMIPOUR M. | Matin Homaie H. | FARZANEGI P. | Issue Writer Certificate

Keywords

High fat diet

Aerobic exercise

Pistachio skin

Apoptosis

Abstract

Background: Fatty diet increases Apoptosis and cardiovascular disease. Therefore, this study aimed to evaluate the effect of 4-week Aerobic exercise along with Pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats. Materials and Methods: This is an experimental study. 12-week-old female rats were randomly divided into 5 groups of 6,Positive control (healthy), negative control (obesity), exercise + obesity, extract + obesity, exercise and extract + obesity (interaction of exercise and extract). Training was done for 4 weeks with moderate intensity of 50-60% Vo2max. Pistachio skin extract was used at a dose of 60 mg per kilogram. qPCR method was used to check gene expression. Results: The results showed that the expression of bax and caspase 3 was higher in the obese group than in the healthy group (P=0. 001). The extract groups, the exercise group and the exercise + extract group had more bax and caspase 3 expression compared to the obese group (P=0. 001). The expression of Bcl-2 in the obese group and the exercise group was lower than the healthy group (P=0. 001). Also, the expression of Bcl-2 was higher in the exercise + extract group than in the obese group (P=0. 001). There was a significant difference between the exercise group and the exercise+extract group with the extract group. Conclusion: High-fat diet increase bax and caspase 3 and decreased Bcl-2 in rats. However, exercise and consumption of green Pistachio skin extract together decrease bax and caspase 3 and increased Bcl-2.

Cites

Impacts of endurance training and crocin supplementation on the apoptotic pathways in rat skeletal muscle following doxorubicin administration

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APA: Copy

KAZEMIPOUR, M., Matin Homaie, H., & FARZANEGI, P.. (2023). The effect of aerobic exercise with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats. FEYZ, 26(5 ), 521-529. SID. https://sid.ir/paper/1081922/en

Vancouver: Copy

KAZEMIPOUR M., Matin Homaie H., FARZANEGI P.. The effect of aerobic exercise with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats. FEYZ[Internet]. 2023;26(5 ):521-529. Available from: https://sid.ir/paper/1081922/en

IEEE: Copy

M. KAZEMIPOUR, H. Matin Homaie, and P. FARZANEGI, “The effect of aerobic exercise with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats,” FEYZ, vol. 26, no. 5 , pp. 521–529, 2023, [Online]. Available: https://sid.ir/paper/1081922/en

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