THE COMPARISON BETWEEN HYDROETHANOLIC EXTRACTION OF PISTACIA ATLANTICA AND SUZIN EFFECTS ON GROWTH INHIBITION OF K562 CELL LINE IN VITRO CONDITION

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KEIKHAEI F.; NAGHSH N.; MODARESI M.

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Journal: Journal of Arak University Medical Sciences Year:2014 | Volume:17 | Issue:6 (87) Page(s): 66-73

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Title

THE COMPARISON BETWEEN HYDROETHANOLIC EXTRACTION OF PISTACIA ATLANTICA AND SUZIN EFFECTS ON GROWTH INHIBITION OF K562 CELL LINE IN VITRO CONDITION

Author(s)

KEIKHAEI F. | NAGHSH N. | MODARESI M. | Issue Writer Certificate

Keywords

PISTACIA ATLANTICA EXTRACTQ2

LEUKEMIAQ2

CYTOTOXICQ2

SUZINQ2

K562Q2

Abstract

Background: LEUKEMIAis a malignant and progressive disease of the Hematopoietic tissues of the body. The pistaciaatlanticatreebase, the geographic inlarge areas ofthe Mediterraneanand theMiddle Eastisgrowing. K562Cell class is considered as laboratory model of chronic phase of human CML. We compared the grow thin hibitory effects SUZIN asa chemicalcompared with pistaciaatlanticaas acombined Zn plantantioxidantcapacityinreducingcancer hasbeen studied.Materials and Methods: Pistachio nutaround Kermanwas collected.then they were dried in room temperature and extraction was performed for48 hours by maceration method.K562 Cell class was incubatedinmedium RPMI-1640 fortifiedwith10% (v/v) FBSand50%Streptomycin-Penicillin.Cytotoxiceffect of hydro- ethanolic extract of pistaciaatlanticaagainst cancer cells K562 was evaluated in three interval by MTT method. Light absorbance by Eliza device was measured in wavelength 540nm. Statistical analysis was performed using SPSS15software and ANOVA test.Results: Pistaciaatlanticain24h and inconcentration100mg/ml and SUZIN in48h and in 12.5mg/ml, 72 h and in 50mg/ml induced growth inhibitionhalf of thecellswereK562.results obtained from changes in cell morphology influenced by hydro-ethanolic extract ofpistaciaatlanticaand SUZINsuggest abnormal transformation of cells that probably represents apoptosis and necrosis.Conclusion: Time and concentration against CYTOTOXICeffect of Pistaciaatlanticahave the combined effect. Whileiron supplementation, alonetimeisdue. Special concentration of pistaciaatlanticahaving high antioxidant capacitywith the SUZINcan be considered as a potential target for inhibitingK562cells in treatment of blood cancer.

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APA: Copy

KEIKHAEI, F., NAGHSH, N., & MODARESI, M.. (2014). THE COMPARISON BETWEEN HYDROETHANOLIC EXTRACTION OF PISTACIA ATLANTICA AND SUZIN EFFECTS ON GROWTH INHIBITION OF K562 CELL LINE IN VITRO CONDITION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 17(6 (87)), 66-73. SID. https://sid.ir/paper/69356/en

Vancouver: Copy

KEIKHAEI F., NAGHSH N., MODARESI M.. THE COMPARISON BETWEEN HYDROETHANOLIC EXTRACTION OF PISTACIA ATLANTICA AND SUZIN EFFECTS ON GROWTH INHIBITION OF K562 CELL LINE IN VITRO CONDITION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2014;17(6 (87)):66-73. Available from: https://sid.ir/paper/69356/en

IEEE: Copy

F. KEIKHAEI, N. NAGHSH, and M. MODARESI, “THE COMPARISON BETWEEN HYDROETHANOLIC EXTRACTION OF PISTACIA ATLANTICA AND SUZIN EFFECTS ON GROWTH INHIBITION OF K562 CELL LINE IN VITRO CONDITION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 17, no. 6 (87), pp. 66–73, 2014, [Online]. Available: https://sid.ir/paper/69356/en

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