IMMUNOMODULATING ACTIVITY OF ALOE VERA IN ANIMAL MODEL OF MULTIPLE SCLEROSIS

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MOSAYEBI GHASEM; GHAZAVI A.; NAGHILI B.; MIRSHAFIEI ABAS

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2009 | Volume:12 | Issue:3 (48) Page(s): 109-115

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Information Journal Paper

Title

IMMUNOMODULATING ACTIVITY OF ALOE VERA IN ANIMAL MODEL OF MULTIPLE SCLEROSIS

Author(s)

MOSAYEBI GHASEM | GHAZAVI A. | NAGHILI B. | MIRSHAFIEI ABAS | Issue Writer Certificate

Keywords

ALOE VERAQ2

TUMOR NECROSIS FACTOR- ALPHAQ2

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISQ3

MULTIPLE SCLEROSISQ2

C57BL/6 MOUSEQ3

Abstract

Background: ALOE VERA species have diverse immunomodulatory and antitumor activities.The present study was set out to define the immunomodulatory activity of ALOE VERA extract on tumor necrosis factor-alpha (TNF-4) and development of EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) as an animal model of MULTIPLE SCLEROSIS (MS).Materials and Methods: In this experimental interventional study, EAE was induced by MOG35-55 peptide and complete Freund's adjuvant in C57BL/6 mice. Mice were placed in two therapeutic groups (n=8 per group) with the same age and weight. Therapy with ALOE VERA extract (120mg/kg/every day given oral) was started on day 5 before the immunization until 25 day after that.EAE control received phosphate buffer alone with same schedule. Signs of disease were recorded daily until the day 25 when mice were bled and sacrificed. Produced TNF-4 by cultured spleen mononuclear cells was detected by ELISA.Results: The ALOE VERA treatment significantly reduced the clinical signs of EAE and delayed onset of disease. Mononuclear cells isolated from spleen of treated-mice with ALOE VERA showed a significant decrease in TNF-4 in compared with control mice (p=0.012).Conclusion: ALOE VERA ameliorated the EAE and reduced TNF-4 level in MS animal model.

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APA: Copy

MOSAYEBI, GHASEM, GHAZAVI, A., NAGHILI, B., & MIRSHAFIEI, ABAS. (2009). IMMUNOMODULATING ACTIVITY OF ALOE VERA IN ANIMAL MODEL OF MULTIPLE SCLEROSIS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 12(3 (48)), 109-115. SID. https://sid.ir/paper/69394/en

Vancouver: Copy

MOSAYEBI GHASEM, GHAZAVI A., NAGHILI B., MIRSHAFIEI ABAS. IMMUNOMODULATING ACTIVITY OF ALOE VERA IN ANIMAL MODEL OF MULTIPLE SCLEROSIS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2009;12(3 (48)):109-115. Available from: https://sid.ir/paper/69394/en

IEEE: Copy

GHASEM MOSAYEBI, A. GHAZAVI, B. NAGHILI, and ABAS MIRSHAFIEI, “IMMUNOMODULATING ACTIVITY OF ALOE VERA IN ANIMAL MODEL OF MULTIPLE SCLEROSIS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 12, no. 3 (48), pp. 109–115, 2009, [Online]. Available: https://sid.ir/paper/69394/en

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