SHORT COMMUNICATION: ASSOCIATION BETWEEN JMJD1A EXPRESSION AND SPERM RETRIEVAL IN NON-OBSTRUCTIVE AZOOSPERMIC PATIENTS

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EELAMINEJAD ZAHRA; FAVAEDI RAHA; MODARRESI TAHEREH; SABBAGHIAN MARJAN; SADIGHI GILANI MOHAMMAD ALI; SHAHHOSSEINI MARYAM

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Journal: Cell Journal (Yakhteh) Year:2018 | Volume:19 | Issue:4 Page(s): 660-665

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Title

SHORT COMMUNICATION: ASSOCIATION BETWEEN JMJD1A EXPRESSION AND SPERM RETRIEVAL IN NON-OBSTRUCTIVE AZOOSPERMIC PATIENTS

Author(s)

Keywords

AZOOSPERMIA

JMJD1A

NONOBSTRUCTIVE

SPERM RETRIEVAL

Abstract

Identification of molecular markers which can predict the outcome of SPERM RETRIEVAL non-invasively in patients with non-obstructive AZOOSPERMIA (NOA) are valuable in clinical andrology. Jumonji domain-containing 1a (JMJD1A) is a significant epigenetic regulator during spermatogenesis, which plays an important role in the differentiation of post-meiotic germ cells into mature spermatozoa. We therefore aimed to examine the potential association between JMJD1Aexpression and the outcome of SPERM RETRIEVAL in patients with NOA. Testicular biopsy specimens from 50 NOA patients with either successful SPERM RETRIEVAL (sperm+, n=22) or failed SPERM RETRIEVAL (sperm-, n=28) were collected and then examined forJMJD1A expression by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, conventional clinical parameters including luteinizing hormone, follicle-stimulating hormone, testosterone, age, and testicular volume were compared between the two NOA groups. The expression ofJMJD1A in the sperm+group was significantly higher than in the sperm- group (P<0.001), however, no significant difference was observed between the two groups in clinical parameters. The receiver operating characteristic (ROC) curve ofJMJD1A expression in predicting the SPERM RETRIEVAL outcome showed a sensitivity of 90.91% and a specificity of 89.29% with significant discriminatory ability between the sperm+and sperm- groups [area under the ROC curve (AUC)=0.91]. This study demonstrates a significant association between the expression ofJMJD1A and the success of sperm recovery in patients with NOA, and thus suggests thatJMJD1A expression quantification in testicular biopsies may be a valuable biomarker along with conventional parameters in predicting the presence of spermatozoa.

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APA: Copy

EELAMINEJAD, ZAHRA, FAVAEDI, RAHA, MODARRESI, TAHEREH, SABBAGHIAN, MARJAN, SADIGHI GILANI, MOHAMMAD ALI, & SHAHHOSSEINI, MARYAM. (2018). SHORT COMMUNICATION: ASSOCIATION BETWEEN JMJD1A EXPRESSION AND SPERM RETRIEVAL IN NON-OBSTRUCTIVE AZOOSPERMIC PATIENTS. CELL JOURNAL (YAKHTEH), 19(4), 660-665. SID. https://sid.ir/paper/694023/en

Vancouver: Copy

EELAMINEJAD ZAHRA, FAVAEDI RAHA, MODARRESI TAHEREH, SABBAGHIAN MARJAN, SADIGHI GILANI MOHAMMAD ALI, SHAHHOSSEINI MARYAM. SHORT COMMUNICATION: ASSOCIATION BETWEEN JMJD1A EXPRESSION AND SPERM RETRIEVAL IN NON-OBSTRUCTIVE AZOOSPERMIC PATIENTS. CELL JOURNAL (YAKHTEH)[Internet]. 2018;19(4):660-665. Available from: https://sid.ir/paper/694023/en

IEEE: Copy

ZAHRA EELAMINEJAD, RAHA FAVAEDI, TAHEREH MODARRESI, MARJAN SABBAGHIAN, MOHAMMAD ALI SADIGHI GILANI, and MARYAM SHAHHOSSEINI, “SHORT COMMUNICATION: ASSOCIATION BETWEEN JMJD1A EXPRESSION AND SPERM RETRIEVAL IN NON-OBSTRUCTIVE AZOOSPERMIC PATIENTS,” CELL JOURNAL (YAKHTEH), vol. 19, no. 4, pp. 660–665, 2018, [Online]. Available: https://sid.ir/paper/694023/en

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