Ethanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Geravand Samira; KARAMI MANIZHEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Basic and Clinical Pathophysiology Year:2020 | Volume:8 | Issue:1 Page(s): 35-41

Download Full-Text

View:

148

Download:

Cites:

Information Journal Paper

Title

Ethanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons

Author(s)

Geravand Samira | KARAMI MANIZHEH | Issue Writer Certificate

Keywords

Ethanol

Acquisition

Novelty-seeking behavior

CA1

Place neuron

Abstract

Background and Objective: Ethanol has undesirable effects on memory and synaptic communication. However, its impact on the learned spatial memory is unclear. We investigated the damaging effects of Ethanol on Place neurons of rat’ s hippocampal CA1. Materials and Methods: Sixty four male Wistar rats (250 g) were administered high (1-8 g/kg) or low (0. 05-0. 1 g/kg) doses of Ethanol intraperitoneally (i. p. ) and tested (10 min) for the Novelty-seeking behavior using the place conditioning box. Sniffing, rearing, grooming, and compartment entering was compared between the first and the last stage, during which the animals had accessibility to the whole device. During the Acquisition phase, the rats daily received Ethanol (i. p. ) and confined in one side of the device for 40 min. The control group solely received saline (1 ml/kg, i. p. ). The achievements were analyzed by ANOVA under α = 0. 05. Results: The Ethanol-acquired animals with the high doses did not recall the information of the familiarization day and displayed a high tendency toward the non-confined side of the box. The rats also showed a reduction in Place neuron synaptic strands. Conclusion: Ethanol disrupts spatial memory and also diminishes CA1 Place neuron’ s fibers.

Cites

No record.

References

Cite

APA: Copy

Geravand, Samira, & KARAMI, MANIZHEH. (2020). Ethanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, 8(1), 35-41. SID. https://sid.ir/paper/694649/en

Vancouver: Copy

Geravand Samira, KARAMI MANIZHEH. Ethanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY[Internet]. 2020;8(1):35-41. Available from: https://sid.ir/paper/694649/en

IEEE: Copy

Samira Geravand, and MANIZHEH KARAMI, “Ethanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons,” JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, vol. 8, no. 1, pp. 35–41, 2020, [Online]. Available: https://sid.ir/paper/694649/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops