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Information Journal Paper

Title

The Effect of Various Fractions of Hemiscorpius lepturus Scorpion (Scorpionida: Hemiscorpiidae) Venom on Hemostatic System in Peripheral Blood of Rats in Comparison to Whole Venom

Pages

  0-0

Abstract

 Background: Hemiscorpius lepturus is the most critical scorpion in Khuzestan, Iran, responsible for the majority of deaths caused by scorpion stings. Objectives: This prospective randomized experimental study was performed from June to August 2019 to investigate the effects of various venom fractions on the hemostatic system. Methods: Lyophilized venom of H. lepturus was sepaRated into six fractions by Sephadex G-50 gel chromatography. A total of 96 Albino male Rats were treated in eight equal groups; Control: 0. 5 ml normal saline (IP); Whole venom group: H. lepturus Lyophilized venom, one mg/kg, IP; F1-F6 groups: Isolated venom fraction 1-6, 0. 12 mg/kg, 0. 43 mg/kg, 0. 08 mg/kg, 0. 18 mg/kg, 0. 06 mg/kg and 0. 13 mg/kg, IP, respectively. Blood sampling was performed at 1, 3, and 24 hours after injection. Results: Plasma fibrinogen was significantly elevated in the whole venom group, while it was significantly decreased in F3, F5, and F6 groups compared to the control group. Prothrombin time (PT) and activated partial thromboplastin time (APTT) assessment revealed that there was a significant prolongation of both tests in whole venom and fraction 5 and 6 receiving groups while fraction 2 only caused a significant PT extension, compared to the control group. Conversely, fraction 3 and 4 resulted in PT and APTT in comparison to the control group. The concentRation of FDP and D-dimer was significantly increased in whole venom and F2 group compared to the control group at all sampling times. Conclusions: It seems that H. lepturusvenomhas both procoagulantandanticoagulant properties which are distinct characteristics of it. Further purification and sequencing of the amino acids in the fraction of peptides can lead to a more precise identification of the mechanisms of venom-induced coagulopathies.

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    APA: Copy

    Khataminia, Ali, RAZI JALALI, MOHAMMAD, JALALI, SEYEDEH MISSAGH, & Jafari, Hedieh. (2020). The Effect of Various Fractions of Hemiscorpius lepturus Scorpion (Scorpionida: Hemiscorpiidae) Venom on Hemostatic System in Peripheral Blood of Rats in Comparison to Whole Venom. JUNDISHAPUR JOURNAL OF HEALTH SCIENCES, 12(3), 0-0. SID. https://sid.ir/paper/694779/en

    Vancouver: Copy

    Khataminia Ali, RAZI JALALI MOHAMMAD, JALALI SEYEDEH MISSAGH, Jafari Hedieh. The Effect of Various Fractions of Hemiscorpius lepturus Scorpion (Scorpionida: Hemiscorpiidae) Venom on Hemostatic System in Peripheral Blood of Rats in Comparison to Whole Venom. JUNDISHAPUR JOURNAL OF HEALTH SCIENCES[Internet]. 2020;12(3):0-0. Available from: https://sid.ir/paper/694779/en

    IEEE: Copy

    Ali Khataminia, MOHAMMAD RAZI JALALI, SEYEDEH MISSAGH JALALI, and Hedieh Jafari, “The Effect of Various Fractions of Hemiscorpius lepturus Scorpion (Scorpionida: Hemiscorpiidae) Venom on Hemostatic System in Peripheral Blood of Rats in Comparison to Whole Venom,” JUNDISHAPUR JOURNAL OF HEALTH SCIENCES, vol. 12, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/694779/en

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