The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2)

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SHARIATI MARINA; AZARBAYJANI MOHAMMAD ALI; KAKA GHOLAMREZA; ZILAEI BOURI SHIRIN

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Journal: Journal of Nutrition, Fasting and Health Year:2020 | Volume:8 | Issue:1 Page(s): 40-47

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Title

The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2)

Author(s)

SHARIATI MARINA | AZARBAYJANI MOHAMMAD ALI | KAKA GHOLAMREZA | ZILAEI BOURI SHIRIN | Issue Writer Certificate

Keywords

Bone

H2O2

Training

Vitamin D

Abstract

Introduction: Various studies have indicated that increased active oxygen species is associated with Bone cell damage. The key role of physical exercise and Vitamin D supplementation on Bone health has been confirmed. The present study aimed to investigate the interactive effects of aerobic exercise with Vitamin D supplementation on the Bone resorption markers in the rats exposed to oxidative damage induced by hydrogen peroxide (H2O2). Methods: This experimental study was conducted on 60 adult male Wistar rats. The animals were randomly divided into 10 groups of six, including H2O2 (1 mmol/kg), H2O2 (2 mmol/kg), H2O2 (1 mmol/kg) with Vitamin D, H2O2 (1 mmol/kg) with endurance Training, H2O2 (1 mmol/kg) with Vitamin D and endurance Training, H2O2 (2 mmol/kg) with Vitamin D, H2O2 (2 mmol/kg) with endurance Training, H2O2 (2 mmol/kg) with Vitamin D and endurance Training, sham (dimethyl-sulfoxide with normal saline), and control. The intervention was performed for eight weeks, and the levels of tartrate-resistant acid phosphatase 5b (TRACP/5B) and N-telopeptides (NTx) were measured using the ELISA assay. Data analysis was performed using the Kolmogorov-Smirnov test, two-way analysis of variance (ANOVA), one-way ANOVA, and Tukey’ s post-hoc test at the significance level of P≤ 0. 05. Results: In the animals administered with 1 and 2 mmol/kg of H2O2, no significant effects were observed on the levels of NTx (P=0. 76 and P=0. 47, respectively) and TRACP/5B (P=0. 48). On the other hand, endurance Training increased the NTx levels in the rats exposed to 2 mmol/kg of H2O2 (P=0. 04), while Vitamin D had no significant effects on the levels of NTx (P=0. 32) and TRACP/5B (P=0. 92). In addition, endurance Training with Vitamin D supplementation had no interactive effects on increased NTx and TRACP/5B in the rats exposed to 1 mmol/kg (P=0. 67 and P=0. 99, respectively) and 2 mmol/kg of H2O2 (P=0. 16 and P=0. 47, respectively). Conclusion: According to the results, endurance Training could significantly increase the NTx level in the rats exposed to the oxidative damage induced by 2 mg/kg of H2O2.

Cites

Effect of Aerobic Training and Vitamin D Consumption on NFATc1 Gene Expression in Bone Tissue of Rats Exposed to H2O2

References

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APA: Copy

SHARIATI, MARINA, AZARBAYJANI, MOHAMMAD ALI, KAKA, GHOLAMREZA, & ZILAEI BOURI, SHIRIN. (2020). The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2). JOURNAL OF NUTRITION, FASTING AND HEALTH, 8(1), 40-47. SID. https://sid.ir/paper/695127/en

Vancouver: Copy

SHARIATI MARINA, AZARBAYJANI MOHAMMAD ALI, KAKA GHOLAMREZA, ZILAEI BOURI SHIRIN. The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2). JOURNAL OF NUTRITION, FASTING AND HEALTH[Internet]. 2020;8(1):40-47. Available from: https://sid.ir/paper/695127/en

IEEE: Copy

MARINA SHARIATI, MOHAMMAD ALI AZARBAYJANI, GHOLAMREZA KAKA, and SHIRIN ZILAEI BOURI, “The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2),” JOURNAL OF NUTRITION, FASTING AND HEALTH, vol. 8, no. 1, pp. 40–47, 2020, [Online]. Available: https://sid.ir/paper/695127/en

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