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Title

Effect of Aerobic Training and Vitamin D Consumption on NFATc1 Gene Expression in Bone Tissue of Rats Exposed to H2O2

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  0-0

Abstract

 Background: Increased reactive oxygen species disrupt the balance between osteoblasts and osteoclasts. Although the role of training (T) and Vitamin D (VD) consumption in Bone health has been shown, there is no accurate information on the role of these two interventions on the nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), as an osteoclast marker. Objectives: Therefore, this study aimed to examine the effect of T and VD on NFATC1 gene expression in Bone tissue of rats exposed to H2O2. Methods: Fifty adult male Wistar rats aged 8-10 weeks and weighing 180 to 220 g were randomly assigned to 10 groups including (1) control (C), (2) dimethyl sulfoxide + normal saline (sham; Sh), (3) 1 mmol/kgH2O2 (1H), (4) 1H+VD, (5) 1H+T, (6) 1H+VD+T, (7) 2 mmol/kg H2O2 (2H), (8) 2H+VD, (9) 2H+T, and (10) 2H+VD+T. The research protocol lasted eight weeks to implement. The levels of NFATC1 gene expression were measured by qRT-PCR. Results: Based on the results, 1H and 2H significantly increased NFATC1 gene expression levels (P = 0. 001). However, T (P = 0. 001), VD (P = 0. 001), and VD+T (P = 0. 001) reduced NFATC1 gene expression in the Bone tissue of rats exposed to 1 and 2 mmol H2O2. Also, NFATC1 gene expression was significantly lower in the 1H+VD+T group than in the 2H + VD group (P = 0. 03). Conclusions: It seems that T and VD consumption both alone and synergistically have a reducing effect on NFATC1 as an osteoclast index in rats exposed to 1 and 2 mmol/kg H2O2.

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    APA: Copy

    Hajavifard, Nasrin, MATIN HOMAEE, HASAN, & HOSSEINI, SEYED ALI. (2020). Effect of Aerobic Training and Vitamin D Consumption on NFATc1 Gene Expression in Bone Tissue of Rats Exposed to H2O2. GENE, CELL AND TISSUE, 7(4), 0-0. SID. https://sid.ir/paper/697025/en

    Vancouver: Copy

    Hajavifard Nasrin, MATIN HOMAEE HASAN, HOSSEINI SEYED ALI. Effect of Aerobic Training and Vitamin D Consumption on NFATc1 Gene Expression in Bone Tissue of Rats Exposed to H2O2. GENE, CELL AND TISSUE[Internet]. 2020;7(4):0-0. Available from: https://sid.ir/paper/697025/en

    IEEE: Copy

    Nasrin Hajavifard, HASAN MATIN HOMAEE, and SEYED ALI HOSSEINI, “Effect of Aerobic Training and Vitamin D Consumption on NFATc1 Gene Expression in Bone Tissue of Rats Exposed to H2O2,” GENE, CELL AND TISSUE, vol. 7, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/697025/en

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